Pyoderma gangrenosum. Response to cyclophosphamide therapy

Newell, Larry M.; Malkinson, Frederick D.

doi:10.1001/archderm.119.6.495

Cited by 26 publications

(8 citation statements)

References 24 publications

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“…Immunosuppressive agents are also necessaries in patients who fail to respond to systemic corticosteroids, or who develop steroid-related side effects. Others treatments in refractory PG have been used such as oral azathioprine [13], cyclophosphamide [14], cyclosporine [15], tacrolimus [16], intravenous immunoglobulin [17] mycophenolate mophetil [18] or methotrexate [19]. Recently, anti-tumor necrosis factor alpha have been reported as effectives in refractory cases [20].…”

Section: Discussionmentioning

confidence: 99%

Leg ulcers in the antiphospholipid syndrome may be considered as a form of pyoderma gangrenosum and they respond favorably to treatment with immunosuppression and anticoagulation

et al. 2010

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Leg ulcers are a manifestation of antiphospholipid syndrome (APS), and characteristically respond poorly to treatment. Because the similar findings both clinical and pathological to pyoderma gangrenosum (PG), we treated these patients with a combination of immunosuppression (steroids, azathioprine or cyclosporine), acetylsalicylic acid and anticoagulation. We evaluated the response to the combined treatment with steroids, immunosuppression, acetylsalicylic acid, anticoagulation and local measures in patients with APS and leg ulcers resembling PG. We studied 8 women with leg ulcers of a cohort of 53 patients with APS (15%). Pathological findings of PG were observed in all patients. Seven patients (87.5%) received cyclosporine as usual for the treatment of PG, and all patients received steroids and anticoagulation with warfarin. Cicatrisation was present in all patients in 7 months. Leg ulcers in patients with APS may be resemble to PG, and their treatment with immunosuppression, acetylsalicylic acid and anticoagulation is effective for this severe and poorly responding condition.

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Section: Discussionmentioning

confidence: 99%

Leg ulcers in the antiphospholipid syndrome may be considered as a form of pyoderma gangrenosum and they respond favorably to treatment with immunosuppression and anticoagulation

et al. 2010

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“…In the most severe and corticorefractary cases, cyclosporine A, tacrolimus, azathioprine, or micophenolate mofetil, ciclophosphamide, clorambucil, intravenous gammaglobulin, thalidomide, etanercept, Infliximab, adalimumab, clofazimine, dapsone, metronidazole and nicotine have been used (14)(15)(16)(17)(18). Some studies have shown that treatment of resistant cases can be done with other immunosuppressants.…”

Section: Discussionmentioning

confidence: 99%

Atypical pyoderma gangrenosum in inflammatory bowel disease: A severe diagnostic challenge

Muñoz

Ugidos

Montiel

et al. 2009

Rev. esp. enferm. dig.

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Pyoderma gangrenosum (PG) is a rare inflammatory and ulcerative disease of the skin of unknown etiology. Diagnosis of PG is based on clinical and histological data and requires the exclusion of other ulcerative diseases of the skin. There is an atypical form of PG that appears generally associated with hematological malignancies and rarely has been described in patients with inflammatory bowel disease (IBD). We describe the case of a patient diagnosed with IBD in whom symptomatology was mainly extraintestinal as atypical PG. Case reportA 39-year-old man was referred to our hospital complaining of diarrhea consisting in passage of six to eight liquid stools containing mucus and small amounts of blood each day. One year before, he had been diagnosed of IBD, likely ulcerative colitis, and was treated with corticosteroids and topical 5-aminosalicilates. At the time of hospitalization, in addition to diarrhea, he showed fever (38 ºC), anemia, leukocytosis and elevated reactive C protein serum levels (20.4 ng/mL). Physical examination revealed the presence of a perianal fistula. The colonoscopy demonstrated hyperemia, edema, friability, and granularity, as well as pinpoint ulceration of the colonic mucosa. These changes were diffuse and extended from the rectum throughout the left colon. Histologicaly, it displayed changes consistent with IBD. The patient was treated with high

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“…Minocycline is a semi-synthetic tetracycline with broad spectrum antibiotic activity. Systemic steroid therapy, although effective in PG, carries an appreciable morbidity and even rnor- tality, so several alternative therapies have been used with efficacy (3)(4)(5). There are some previous reports that have suggested that minocycline might be efficacious in PG (1).…”

Section: Discussionmentioning

confidence: 99%

Minocycline Hydrochloride Hyperpigmentation Complicating Treatment of Pyoderma Gangrenosum

Miralles

Núñez

Pérez

et al. 1994

The Journal of Dermatology

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Minocycline-associated hyperpigmentation is an uncommon side effect. We report the case of a patient with pyoderma gangrenosum successfully treated with oral minocycline but complicated by marked hyperpigmentation in his pyoderma gangrenosum and acne scars. One of the clinical forms of minocycline hyperpigmentation includes dark-blue or black macules in depressed acne scars or other sites of skin inflammation; this pattern seems to be independent of the total cumulative dose and the skin process.

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Pyoderma gangrenosum. Response to cyclophosphamide therapy

Cited by 26 publications

References 24 publications

Leg ulcers in the antiphospholipid syndrome may be considered as a form of pyoderma gangrenosum and they respond favorably to treatment with immunosuppression and anticoagulation

Leg ulcers in the antiphospholipid syndrome may be considered as a form of pyoderma gangrenosum and they respond favorably to treatment with immunosuppression and anticoagulation

Atypical pyoderma gangrenosum in inflammatory bowel disease: A severe diagnostic challenge

Minocycline Hydrochloride Hyperpigmentation Complicating Treatment of Pyoderma Gangrenosum

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