Pyoderma gangrenosum, polycythemia rubra vera, and the development of leukemia

Ho, Kenneth; Otridge, B.; Vandenberg, E; Powell, Frank C.

doi:10.1016/0190-9622(92)70252-b

Cited by 46 publications

(25 citation statements)

References 34 publications

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“…13 PG can occur concomitant to the hematological disease or, during its evolution, as marker of the malignant transformation of a previously stable disease. 8 As in the case reported, PG can be the cutaneous manifestation of a systemic disease. The possibility of MDS should always be considered in patients with pyoderma gangrenosum presenting by mono-, bi-or pancytopenia.…”

Section: Discussionmentioning

confidence: 98%

“…5 Up to 54% of the reported cases of PG associated with leukemia were of the bullous subtype. 8 The outbreak of BPG can be an indication of reserved prognosis in these diseases. 5 The case reported shows the association between PG, especially the bullous variant, and MDS, of the refractory cytopenia with multilineage dysplasia subtype (RCMD).…”

Section: Introductionmentioning

confidence: 99%

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Pioderma gangrenoso bolhoso e síndrome mielodisplásica

Batista

Fernandes

Rocha

et al. 2006

An. Bras. Dermatol.

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Pyoderma gangrenosum can present as a cutaneous manifestation of paraneoplastic syndromes. A case of bullous pyoderma gangrenosum associated with bicytopenia is described. During the complementary investigation, myelogram, bone marrow biopsy and karyotype were performed, and showed a pattern consistent with myelodysplastic syndrome. The patient was treated with dapsone with improvement. Pyoderma gangrenosum can be a manifestation of systemic diseases. The possibility of myelodysplastic syndrome should always be considered in patients with pyoderma gangrenosum associated with cytopenia.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Pioderma gangrenoso bolhoso e síndrome mielodisplásica

Batista

Fernandes

Rocha

et al. 2006

An. Bras. Dermatol.

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“…18,19 After establishing the diagnosis of pyoderma gangrenosum, patients should undergo evaluation for associated diseases by their primary physicians, because up to 50% of patients with pyoderma gangrenosum have an associated systemic disease. Pustular PG is most commonly encountered in patients with active inflammatory bowel disease, 9 bullous PG is associated with a high frequency of myelodysplastic disease, 11 and vegetative PG is usually not associated with any systemic disease. 12 Surgical consultation for debridement of a nondiagnosed ulcerative process is ill advised and may exacerbate the disease process.…”

Section: Goldfrank Et Al • Ed Categorization Standardsmentioning

confidence: 99%

“…This superficial variant is usually less destructive to the deeper tissue than the typical ulcerative PG and is characterized by painful bullae. 11 Vegetative PG is a limited, nonaggressive, chronic, superficial variant that has recently been termed ''superficial granulomatous pyoderma.'' These ulcerative lesions are usually more superficial with a less violaceous, non-undermined border.…”

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confidence: 99%

Clinical Pearls: Ulcers on the Fingers

Manthey

Schissel

1999

Academic Emergency Medicine

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Chief Complaint. Ulcers on the thumb and index finger. History of Present Illness.A 68-year-old woman presents to the ED for evaluation of ulcers on her left thumb and right index finger that appeared after minor trauma. The lesions began as tender erythematous nodules, which progressed and coalesced to pustules. The pustules gradually became more erythematous and began to ulcerate. A dusky hue developed around the margins of the ulcers. This process occurred over a ten-day period.The patient states she had a similar ulcerative process on the buttock and upper thigh region. Treatment at that time included surgical resection of the lesions, which resulted in spreading of the lesions. Subsequently, she was evaluated by a dermatologist and started on oral corticosteroids. The ulcerations slowly resolved, leaving her with large hypertrophic reticulated scars.She denies chemical exposure or arthropod envenomation. She denies diarrhea, bloody stool, fevers, headaches, and joint pain.Physical Examination. The patient's physical examination is normal except for the hands, which reveal 2.7-cm ulcerated lesions on the left thumb ( Fig. 1) and a 1.7-cm lesion on the distal aspect of the right index finger (Fig. 2) Laboratory Studies. The patient has a normal white blood cell count and a normal erythrocyte sedimentation rate.(The diagnosis and discussion appear on page 655.)

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“…Thromboembolic events are important causes of morbidity and mortality [1]. Various paraneoplastic and immunologically mediated diseases associated with PV such as pyoderma gangrenosum, Sweet's syndrome, leukocytoclastic vasculitis, autoimmune hemolytic anemia, and ulcerative colitis have been described [2][3][4][5][6]. Here, a patient with PV who had pyoderma gangrenosum and developed acute renal failure due to rapidly progressive glomerulonephritis (RPGN) is presented.…”

mentioning

confidence: 99%