Pyoderma gangrenosum in infancy: The youngest reported patient

Pediatric pyoderma gangrenosum: a systematic review and update

“…[7][8][9] Cases in infants and adolescents account for only 4% of PG, with a higher incidence of head and perineal involvement, preponderance of pustular lesions, and a frequent history of trauma. 26 In addition to oral 10 and intralesional corticosteroids, 27 pulse intravenous dexamethasone, 28 cyclosporine, 29 colchicine, 18 thalidomide, 30 sulfa drugs, 31 azathioprine, 18 mycophenolate mofetil, 32 tumor necrosis alpha inhibitors, [33][34][35][36] calcineurin inhibitors, 37 IL-1, 38 intravenous immunoglobulin, 39 and surgery 27 have recently been shown to be effective in the treatment of adult and pediatric PG. 13,14 drug therapies like pegfilgrastima granulocyte-stimulating factor, 23 and gefitiniban inhibitor of epidermal growth factor receptor 24 and with autoinflammatory syndromes like Pyogenic Arthritis, Pyoderma gangrenosum and Acne (PAPA) syndrome 25 and Majeed syndrome.…”

Infantile pyoderma gangrenosum

“…Systemic therapy is usually required to control the disease in this age group, evidenced by the fact that 11 of the 12 reported infants with PG had treatment with systemic steroids. [2][3][4][5][6][7][9][10][11][12][13] Eight were treated with oral steroid, 2-5,10-13 one with intravenous steroid, 7 and two with both intravenous and oral steroids. 6,9 Other systemic treatments included dapsone, 2,3,6 colchicine, 3 azathioprine, 3 sulfasalazine, and 6-mercaptopurine.…”

“…It has been estimated that 4% of PG cases are in infants and children 1 and, to our knowledge, there are only 12 cases reported in the literature of PG in infants (\1 year of age). [2][3][4][5][6][7][8][9][10][11][12][13] Eight of the reported patients with infantile PG had an underlying medical condition (Table I). Two infants had Takayasu's arteritis, 2,3 one of whom also had sterile osteomyelitis 3 and one further patient had chronic recurrent multifocal osteomyelitis.…”

Pyoderma gangrenosum in an infant: A case report and review of the literature

“…It is often associated with a concomitant disease, although up to half of cases are considered idiopathic . Infantile PG is even less common, with only 20 cases reported, 11 of which are described as idiopathic, whereas the others are associated with a spectrum of inflammatory, hematologic, and infectious disorders (Table ) . With this report, we add another patient with infantile PG and review the literature for potential treatments.…”