Pyoderma Gangrenosum Following Cesarean Delivery

Pathophysiology of pyoderma gangrenosum (PG): An updated review

“…[40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56] A portion of these cases may be explained by pathergy as they occurred at the site of cesarean section [40][41][42][43][44][45][46][47][48][49] or on the extremities, 40,[50][51][52][53][54][55][56] which are more prone to trauma. Two patients possessed a background of systemic inflammatory disease (relapsing polychondritis 50 and antiphospholipid syndrome 51 ), likely contributing to a predilection for PG formation.…”

Pyoderma gangrenosum: A case report of bilateral dorsal hand lesions and literature review of management

“…Examining therapeutic options, it is clear why differentiation is important. Treatment of infectious processes involves systemic antimicrobials, which have no effect on PG, as well as debridement and excision of affected tissues, which can exacerbate the wound with worsening inflammation and ulceration through a phenomenon known as pathergy (11)(12)(13). Conventional treatment of PG involves gentle local wound care and systemic immunosuppression, which could prove disastrous in the setting of a necrotizing infection.…”

Pyoderma gangrenosum following surgical procedures

“…Histological features are not pathognomonic. There are several reports of PG occurring at percutaneous surgical sites, such as breast surgery, pacemaker implantation, splenectomy, hysterectomy, endoscopic tube insertion, cholecystectomy, and cesarean delivery 1–8 . These results suggest that pathergy reaction is implicated as a triggering role in the induction of PG in patients with susceptible disposition.…”