Pyoderma gangrenosum developing over an arteriovenous fistula scar

Castillo, Rafael Fernández; Fuente, Guillermo A. Cañadas‐De la; Husein‐ElAhmed, Husein; Cantero-Hinojosa, J.

doi:10.1111/j.1445-5994.2011.02479.x

Cited by 7 publications

(6 citation statements)

References 5 publications

(5 reference statements)

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“…The most common locations for PG found in these patients include the lower extremities, skin overlying an arteriovenous fistula, and previous surgery sites [3,11,26,53]. Furthermore, ulcerative, vegetative, and atypical PG have been reported in this patient population [3,11,21,26,53]. Even though CKD is a risk factor for wound healing Fig.…”

Section: Pg and Renal Involvementmentioning

confidence: 77%

“…It may present as pyuria, hematuria, aseptic leukocyturia, oliguria, and proteinuria as a result of different types of renal compromise [9,10,39,57]. Though few in number, several renal conditions have reportedly been associated with PG, such as chronic sclerosing glomerulonephritis, chronic kidney disease, end-stage renal disease (ESRD), renal carcinoma, and renal transplant, among others [3,4,6,11,26,29,33,49,53,57] (Fig. 2).…”

Section: Pg and Renal Involvementmentioning

confidence: 99%

“…Few cases have reported the association of PG with chronic kidney disease and end-stage renal disease (CKD/ ESRD); however, the underlying pathophysiology is yet to be elucidated [11,26,29,53]. Several theories have been proposed about the underlying mechanism of PG in patients with CKD/ESRD.…”

Section: Pg and Renal Involvementmentioning

confidence: 99%

“…Akatsuka et al suggested the presence of monoclonal gammopathy (MG) as the possible cause of PG-associated CKD, in which MG leads to a rapidly progressive renal failure [3]. Others propose a mechanism that might include an underlying vascular insufficiency, especially in patients with ulcerative PG in the lower extremities [11]. The most common locations for PG found in these patients include the lower extremities, skin overlying an arteriovenous fistula, and previous surgery sites [3,11,26,53].…”

Section: Pg and Renal Involvementmentioning

confidence: 99%

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Extracutaneous involvement of pyoderma gangrenosum

et al. 2019

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Pyoderma Gangrenosum (PG) is an inflammatory neutrophilic dermatosis (ND) associated with underlying chronic inflammation and/or malignancy. Diagnosis remains to be challenging as a gold standard diagnostic test is lacking. Initial manifestations may include papules, vesicles, or pustules that subsequently develop into ulceration with features of undermining and violaceous borders. Timely recognition of pyoderma gangrenosum is impeded by clinical findings shared with other etiologies, such as granulomatosis with polyangiitis, polyarteritis nodosa, and antiphospholipid syndrome. As with any other ND, extracutaneous involvement may also occur preceding, during, or following the appearance of skin lesions. Sterile neutrophilic infiltrates have been found to affect internal organs supporting the concept of PG being a systemic disease, with lung being the most common extracutaneous manifestation followed by ocular and visceral compromise. Therefore, in this review, we describe the current knowledge of extracutaneous involvement of PG and its respective clinical manifestations to aid dermatologists in diagnosis, management, and determining prognosis.

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Section: Pg and Renal Involvementmentioning

confidence: 77%

Section: Pg and Renal Involvementmentioning

confidence: 99%

Section: Pg and Renal Involvementmentioning

confidence: 99%

Section: Pg and Renal Involvementmentioning

confidence: 99%

See 2 more Smart Citations

Extracutaneous involvement of pyoderma gangrenosum

et al. 2019

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“…The increased risk of PG in patients with preexisting renal disease observed in our analysis has also been reported in several case reports. The most frequent renal conditions that were implicated in eliciting PG were KT [16][17][18], end-stage renal disease (ESRD) [19][20][21] CRF [22], and renal carcinoma [23].…”

Section: Discussionmentioning

confidence: 99%

Chronic renal comorbidities in pyoderma gangrenosum: a retrospective cohort study

et al. 2021

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The coexistence of pyoderma gangrenosum (PG) and chronic renal comorbidities has been reported anecdotally. We aimed to assess the bidirectional association between PG and the following chronic renal comorbidities: chronic renal failure (CRF), dialysis, kidney transplantation (KT), and other kidney diseases (OKD). That is to evaluate (i) the risk of the aforementioned diseases among patients with PG (ii) and the odds of PG after a diagnosis of renal comorbidities. A population-based retrospective cohort study was conducted comparing PG patients (n=302) with age-, sex-, and ethnicity-matched control subjects (n=1497) with regard to incident cases of renal comorbidities. A case-control design was additionally adopted to estimate the odds of PG in those with a preexisting history of renal comorbidities. Adjusted hazard ratios (HRs) and adjusted odds ratios (ORs) were estimated by Cox regression and logistic regression, respectively. Patients with PG demonstrated an increased risk of CRF (adjusted HR, 3.68; 95% CI, 2.72–5.97), dialysis (adjusted HR, 27.79; 95% CI, 3.24–238.14), and OKD (adjusted HR, 2.71; 95% CI, 1.55–4.74). In addition, the odds of PG were increased after the diagnosis of CRF (adjusted OR, 2.34; 95% CI, 1.33–4.11), KT (adjusted OR, 5.03; 95% CI, 1.01–25.12), and OKD (adjusted OR, 1.69; 95% CI, 1.04–2.74). Patients with a dual diagnosis of PG and renal diseases presented with PG at an older age and had a higher prevalence of comorbid conditions. In conclusion, a bidirectional association exists between PG and chronic renal conditions. Awareness of this comorbidity may be of benefit for physicians managing patients with PG.

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