Pyoderma gangrenosum associated with erythroid hypoplasia

Abstract

Summary Pyoderma gangrenosum is most commonly associated with inflammatory bowel disease and rheumatoid arthritis, but it has been associated with various haematological malignancies. We describe its association with primary erythroid hypoplasia without thymoma in an 80 year old woman who presented with septicaemia complicating urinary tract infection. Spontaneous healing of an extensive lesion was observed.

Pyoderma Gangrenosum in a Patient With Hereditary Spherocytosis

“…1 Associated hematologic diseases encompass several types of anemia, including myelofibrosis with anemia, paroxysmal nocturnal hemoglobinuria, Fanconi’s anemia, erythroid hypoplasia, and autoimmune hemolytic anemia. 1,5-8 To the best of our knowledge, an association with HS has not been previously described. HS is a congenital autohemolytic disorder inherited as a dominant trait, although a recessive pattern and new mutations may occur.…”

Pyoderma gangrenosum in a patient with autoimmune haemolytic anaemia and complement deficiency

“…10 Several types of anaemia have been described with PG, including patients with myelofibrosis and anaemia, 11,12 paroxysmal nocturnal haemoglobinuria, 13 Fanconi's anaemia 14 and erythroid hypoplasia. 15 To our knowledge, association with autoimmune haemolytic anaemia has been described only once previously, 16 in a patient who additionally suffered from Crohn's disease and a monoclonal gammopathy (which we suggest to be possibly more important associations).…”

Pyoderma gangrenosum with pure red cell aplasia

“…The relation between pyoderma gangrenosum and pure red cell aplasia is found to be rare in the literature. Only two adult cases (a 72-year old man and an 80-year old woman) have been reported so far with this rare association (8,9) and no cases reported in the pediatric age group. This type of pure red cell aplasia is often associated with neoplasia, mostly thymoma.…”