Pyoderma gangrenosum associated with acute myeloproliferative disease (? erythroleukaemia)

Toolis, Francis; Parker, A. C.; Barnetson, R S

doi:10.1136/pgmj.54.638.830

Cited by 6 publications

(1 citation statement)

References 3 publications

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“…However, its association with acute myeloproliferative disease (Toolis et at., 1978;Caughman et at., 1983) and the myelodysplastic or preleukaemic syndromes appears to have been less well described. The latter poses particularly difficult therapeutic challenges since the available evidence in rheumatoid arthritis and ulcerative colitis, as well as with our sixth patient, suggests that healing of the ulcer is only likely to occur once underlying disease has either been controlled or eradicated.…”

Section: Discussionmentioning

confidence: 99%

Pyoderma gangrenosum in myelodysplasia and acute leukaemia

Jacobs

Palmer

Gordon‐Smith

1985

Postgraduate Medical Journal

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Summary Pyoderma gangrenosum is a rare occurrence in patients with haematological malignancy. This characteristic but nonspecific inflammatory process with skin destruction occurred in 4 patients with myelodysplasia, in one with acute leukaemic transformation of myelofibrosis, and in de novo acute myeloblastic leukaemia in another. Clinically, the cutaneous lesion in these patients differed from that associated with inflammatory bowel disease, arthritis, or the idiopathic type of pyoderma gangrenosum by having the vesiculo-bullous borders. Histopathological differences were also evident since more superficial layers of the skin were involved in the ulceration than typically encountered in patients with non-malignant systemic disease. Despite the less penetrating nature of this variant, treatment of the pyoderma gangrenosum is unsatisfactory and in the absence of effective therapy for the underlying disease, healing occurred only in the patient with acute leukaemia who achieved complete remission in response to chemotherapy.

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Section: Discussionmentioning

confidence: 99%