Pyoderma Gangraenosum

Pyoderma gangrenosum: From historical perspectives to emerging investigations

“…He instead posited the cause to be a vitamin deficiency, partially influenced by the knowledge of vitamin deficiency as a common occurrence in UC. 31 The cause of UC itself had several different considerations then, notably including infection, and the idea of a primarily infectious, bacterial aetiology for PG continued to prevail through the 1950s. 20,21,32,33 F I G U R E 3 Landmark 1930 case series describing and naming pyoderma gangrenosum (PG) 10…”

“…The idea of an “allergic” pathogenesis involving sensitisation of the skin to bacteria was also suggested by Michelson and Bruning 30 in Germany at the time, although it is unclear the specific definition of “allergy” in this context. The first well‐documented, exclusively noninfectious explanation was proposed by Cohen 31 in 1936, who suggested that previously isolated organisms such as streptococci, staphylococci, and Pseudomonas aeruginosa , were “secondary invaders.” He instead posited the cause to be a vitamin deficiency, partially influenced by the knowledge of vitamin deficiency as a common occurrence in UC 31 . The cause of UC itself had several different considerations then, notably including infection, and the idea of a primarily infectious, bacterial aetiology for PG continued to prevail through the 1950s 20,21,32,33 …”