Pyoblepharitis Vegetans in Association With Pyodermatitis-Pyostomatitis Vegetans

Dupuis, Elaine; Haber, Richard M.; Robertson, Lynne

doi:10.1177/1203475415615324

Cited by 4 publications

(4 citation statements)

References 12 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 Ocular involvement is rare, with < 10 cases reported. 3 Inflammatory bowel disease (IBD) is associated with PDV-PSV in 70% of cases, 2 and most patients have active disease at the time of presentation, 1,2 which was evident in our case. In a minority of cases for which there is no known history of IBD, investigation for IBD is recommended.…”

Section: P Dsupporting

confidence: 49%

See 1 more Smart Citation

Pyodermatitis vegetans–pyostomatitis vegetans with ocular involvement

Steele

Jeetle

Kok

et al. 2020

Clin Experimental Derm

View full text Add to dashboard Cite

A 48-year-old woman with Crohn disease (CD) presented with a 5-day history of bloody diarrhoea, a painful mouth and a pustular rash. Physical examination revealed large, tender pustules affecting the right dorsal foot (Fig. 1a), which broke down to form vegetative plaques (Fig. 1b). Smaller, single papulopustules were present on the left foot, right elbow and head. There was a painful stomatitis with widespread confluent papulopustules (Fig. 1c,d). The vulval mucosa was similarly affected. The patient

show abstract

Section: P Dsupporting

confidence: 49%

“…PDV describes cutaneous lesions, which most commonly affect the scalp and intertriginous areas, 1,2 and PSV describes oral pustules that break down to ‘snail‐tract’ erosions/ulceration 1 . Ocular involvement is rare, with < 10 cases reported 3 …”

Section: Figurementioning

confidence: 99%

Pyodermatitis vegetans–pyostomatitis vegetans with ocular involvement

Steele

Jeetle

Kok

et al. 2020

Clin Experimental Derm

View full text Add to dashboard Cite

show abstract

“…Anogenital areas are occasionally affected and refractory erosive erythema are observed. By contrast, ocular involvement is rarely reported 4–6 …”

Section: Clinical Featuresmentioning

confidence: 99%

“…By contrast, ocular involvement is rarely reported. [4][5][6] Peripheral blood eosinophilia was observed in patients with pyodermatitis pyostomatitis vegetans. In our four patients, the eosinophil to neutrophil ratio was between 1:2.5 and 1:5.…”

mentioning

confidence: 99%

Local neutrophil and eosinophil extracellular traps formation in pyodermatitis pyostomatitis vegetans

Yamamoto

2023

Experimental Dermatology

View full text Add to dashboard Cite

Pyodermatitis pyostomatitis vegetans is a rare inflammatory condition, affecting the skin and/or mucous membrane. Some cases include both skin and mucous involvement, whereas others develop either skin or mucous lesions only. The typically affected areas are the scalp, face, trunk and extremities, including the flexural areas and umbilicus. Clinical features show erosive granulomatous plaques, keratotic plaques with overlying crusts and pustular lesions. Among mucous lesions, oral mucosa is most frequently involved, and gingival erythema, shallow erosions, cobblestone‐like papules on the buccal mucosa or upper hard palate of the oral cavity are also observed. Some of the lesions assume a ‘snail track’ appearance. Although there are several similarities between pyodermatitis pyostomatitis vegetans and other diseases, that is pyoderma gangrenosum, pemphigus vegetans and pemphigoid vegetans, the histopathological features of pyodermatitis pyostomatitis vegetans are unique in that epidermal hyperplasia, focal acantholysis and dense inflammatory infiltrates with intraepidermal and subepidermal eosinophilic microabscesses are observed. Direct immunofluorescence findings are principally negative. Activated neutrophils are supposed to play an important role in the pathogenesis of pyodermatitis pyostomatitis vegetans. The expression of IL‐36 and neutrophil extracellular traps (NETs) was observed in the lesional skin, and additionally, eosinophil extracellular traps (EETs) was detected in pyodermatitis pyostomatitis vegetans. A possible pathogenic role of NETs and EETs in the innate immunity and autoinflammatory aspects of pyodermatitis pyostomatitis vegetans was discussed.

show abstract