Pyloric Stenosis in Twins

Hypertrophic pyloric stenosis: adult and congenital types occurring in the same family.

“…In relatives of female index patients there are 15 40 affected males (30 times higher) and 9-8% females (100 times higher). Twin studies have shown a higher rate of concordance in monozygotic than in dizygotic twins, though there is discordance in 3050% of the monozygotic pairs (Powell and Carter, 1951;Metrakos, 1953;MacMahon and McKeown, 1955). These findings are all in accord with those expected in multifactorial genetic inheritance.…”

Congenital Hypertrophic Pyloric Stenosis in Twins

“…Furthermore in both of these sets of twins there was additional supporting evidence for monozvgositv. In Powell and Carter's (1951) three twin pairs (Nos. 107, 108 and 110), and in my own case (No.…”

“…This possibility has been ruled out particularly well in the three twin pairs reported by Powell and Carter (1951), for the healthy twin in each case was examined with considerable care including close observation for peristalsis during a feed. In two of the pairs, the normal twin was also examined radiologically, but no obstruction was noted and there was no delay in eliminating the barium.…”

Infantile hypertrophic pyloric stenosis: data on 81 pairs of twins

“…Using cases reported in the literature, Laubscher & Smith (1947) found 11 examples of concordance in 13 monozygous pairs, and 1 in 23 dizygous pairs. Powell & Carter (1951) added 4 pairs of their own to others previously published, and noted that both twins were affected in 12 of 17 monozygous pairs, and in 3 of 29 dizygous pairs; corresponding figures reported by Metrakos (1953) were 12 in 18 and 1 in 29 respectively. The impression remains that the incidence of concordance is substantially greater in monozygous than in dizygous twins.With the exception of Sheldon's series, which included only one undoubtedly monozygous pair, all of the series upon which this conclusion is based were composed largely of published cases, which can by no means be accepted as representative.…”