Pylephlebitis nach Nabelvenenkatheterismus

Focal Bacterial Infections

“…The etiologic agents in the infants described by Dehner and Kissane [3], Moss and Pysher [5], Chusid [6], and included Escherichia coli, S. aureus, Pseudomonas aeruginosa, *References [5,6,21,22,25,28,32,[34][35][36][37][38][39][40][41].…”

“…with solitary [5,6,[20][21][22]32,[34][35][36][37][38][39][40] or multiple [5,75,76] hepatic abscesses. In three large series, including almost 500 infants who died after placement of umbilical vein catheters, 29 infants were found to have purulent infections of hepatic vessels or parenchyma [37,75,77].…”

“…with solitary [5,6,[20][21][22]32,[34][35][36][37][38][39][40] or multiple [5,75,76] hepatic abscesses. In three large series, including almost 500 infants who died after placement of umbilical vein catheters, 29 infants were found to have purulent infections of hepatic vessels or parenchyma [37,75,77]. Use of venous catheters for infusion of hypertonic or acidic solutions may provide a necrotic focus for abscess formation [21,32,[34][35][36]76,77], and prolonged [5,22,32,77] or repeated [63] catheterization of a necrotic umbilical stump provides an ideal pathway for introduction of pathogenic organisms.…”

“…Subsequently, patients have been successfully treated with empirical antibiotic therapy alone [91,92]. Conservative medical management in infants has been described in only two neonates and a 5-month-old infant [33,37,78].…”