PYCR2 promotes growth and aerobic glycolysis in human liver cancer by regulating the AKT signaling pathway

Wang, Shaoyan; Yi, Wenyan; Xu, Zhenyu; Shi, Minyu

doi:10.1016/j.bbrc.2023.09.007

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2024

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Cited by 4 publications

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PYCR2, induced by c-Myc, promotes the invasiveness and metastasis of breast cancer by activating AKT signalling pathway

Wu,

Qin,

et al. 2024

The International Journal of Biochemistry & Cell Biology

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PYCR2, induced by c-Myc, promotes the invasiveness and metastasis of breast cancer by activating AKT signalling pathway

Wu,

Qin,

et al. 2024

The International Journal of Biochemistry & Cell Biology

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Cardiac endothelial ischemia/reperfusion injury-derived protein damage-associated molecular patterns disrupt the integrity of the endothelial barrier

Kumphune,

Seenak,

Paiyabhrom

et al. 2024

Heliyon

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Deciphering the effects of PYCR family on cell function, prognostic value, immune infiltration in ccRCC and pan-cancer

Chen,

Chen

et al. 2024

Preprint

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Background Pyrroline-5-carboxylate reductase (PYCR) is pivotal in converting pyrroline-5-carboxylate (P5C) to proline, the final step in proline synthesis. Three isoforms, PYCR1, PYCR2, and PYCR3, existed and played significant regulatory roles in tumor initiation and progression. Methods In this study, we firstly assessed molecular and immune characteristics of PYCRs by a pan-cancer analysis, especially focusing on their prognostic relevance. Then, a kidney renal clear cell carcinoma (KIRC)-specific prognostic model was established, incorporating pathomics features to enhance predictive capabilities. The biological functions and regulatory mechanisms of PYCR1 and PYCR2 were investigated by in vitro experiments in renal cancer cells. Results The PYCRs’ expressions were elevated in diverse tumors, correlating with unfavorable clinical outcomes. PYCRs were enriched in cancer signaling pathways, significantly correlating with immune cell infiltration, tumor mutation burden (TMB), and microsatellite instability (MSI). In KIRC, a prognostic model based on PYCR1 and PYCR2 was independently validated statistically. Leveraging features from H&E-stained images, a pathomics feature model reliably predicted patient prognosis. In vitro experiments demonstrated that PYCR1 and PYCR2 enhanced the proliferation and migration of renal carcinoma cells by activating the mTOR pathway, at least in part. Conclusion This study underscores PYCRs' pivotal role in various tumors, positioning them as potential prognostic biomarkers and therapeutic targets, particularly in malignancies like KIRC. The findings emphasize the need for broader exploration of PYCRs' implications in pan-cancer contexts.

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PYCR2 promotes growth and aerobic glycolysis in human liver cancer by regulating the AKT signaling pathway

Cited by 4 publications

References 36 publications

PYCR2, induced by c-Myc, promotes the invasiveness and metastasis of breast cancer by activating AKT signalling pathway

PYCR2, induced by c-Myc, promotes the invasiveness and metastasis of breast cancer by activating AKT signalling pathway

Cardiac endothelial ischemia/reperfusion injury-derived protein damage-associated molecular patterns disrupt the integrity of the endothelial barrier

Deciphering the effects of PYCR family on cell function, prognostic value, immune infiltration in ccRCC and pan-cancer

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