Pycnogenol supplementation reduces pain and stiffness and improves physical function in adults with knee osteoarthritis

Farid, Reza; Mirfeizi, Zahra; Mirheidari, Mahyar; Rezaieyazdi, Zahra; Mansouri, Hassan; Esmaelli, Habib; Zibadi, Sherma; Rohdewald, Peter; Watson, Ronald R.

doi:10.1016/j.nutres.2007.09.007

Cited by 53 publications

(51 citation statements)

References 17 publications

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“…In the 3 month study of pycnogenol (150 mg/day), a potent flavonoid-rich dietary extract, significant decreases in pain and improved physical function in comparison to the nonanalgesic placebo were indicated. 27 Though they observed no statistical differences between groups with regard to stiffness, an improvement was noted from baseline to final in those receiving the supplement. Our findings are in agreement, as we report notable alterations in stiffness among both groups after only 1 week.…”

Section: Discussionmentioning

confidence: 92%

A Combination of Scutellaria Baicalensis and Acacia Catechu Extracts for Short-Term Symptomatic Relief of Joint Discomfort Associated with Osteoarthritis of the Knee

Arjmandi

Ormsbee

Elam

et al. 2014

Journal of Medicinal Food

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The extracts of Scutellaria baicalensis and Acacia catechu have been shown in previous studies to alleviate joint discomfort, reduce stiffness, and improve mobility by reducing the production of proinflammatory molecules over long periods of supplementation. The acute effects of intake of these extracts have not yet been investigated. Thus, we carried out a 1 week clinical trial to examine the extent to which UP446-a natural proprietary blend of S. baicalensis and A. catechu (UP446)-decreases knee joint pain, mobility, and biomarkers of inflammation in comparison to naproxen. Seventy-nine men and women (40-90 years old) diagnosed as having mild to moderate osteoarthritis (OA) consumed either 500 mg/day of the UP446 supplement or 440 mg/day of naproxen for 1 week in a double-blind randomized control trial. Pain, knee range of motion (ROM), and overall physical activity were evaluated at the start and at the end of treatment. Fasting blood was collected to determine serum interleukins 1b and 6, tumor necrosis factor-a, C-reactive protein, and hyaluronic acid. The UP446 group experienced a significant decrease in perceived pain (P = .009) time dependently. Stiffness was significantly reduced by both treatments (P = .002 UP446, P = .008 naproxen). Significant increases in mean ROM over time (P = .04) were found in the UP446 group. These findings suggest that UP446 is effective in reducing the physical symptoms associated with knee OA.

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Section: Discussionmentioning

confidence: 92%

A Combination of Scutellaria Baicalensis and Acacia Catechu Extracts for Short-Term Symptomatic Relief of Joint Discomfort Associated with Osteoarthritis of the Knee

Arjmandi

Ormsbee

Elam

et al. 2014

Journal of Medicinal Food

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“…A significant improvement in WOMAC score was observed in test group lowering the frequency of NSAIDs or COX-2 inhibitors usage compared to placebo group with increased medication. The study indicated the efficacy of PBE in osteoarthritis (Farid et al, 2007). This promising trial in a very common disease effecting millions of people needs further studies with large number of patients.…”

Section: Osteoarthritis and Pbementioning

confidence: 85%

A review on biological, nutraceutical and clinical aspects of French maritime pine bark extract

Maimoona

Naeem

Saddiqe

et al. 2011

Journal of Ethnopharmacology

149

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“…Moreover, it has also been shown that procyanidin B1 inhibited the transactivation of NFB driven genes and the increase of NFB-DNA nuclear binding in jurkat T cells (32). On the other hand, anti-inflammatory effects of another pine bark extract were observed in animals with inflammatory bowel disease (33) and in patients with knee osteoarthritis (18). From these observations, it is possible that proanthocyanidin B1, catechin, epicatechin, and other substances in the FG mixture showed additive or synergistic effects on collageninduced arthritis, probably mediated by these antiinflammatory or immunomodulatory actions.…”

Section: Discussionmentioning

confidence: 99%

“…OPCs have powerful antioxidative activity ( 11 ) and have been shown to prevent or attenuate atherosclerosis ( 12 ), diabetes ( 13 , 14 ), and hypertension ( 15 ). Furthermore, it has been shown that another French maritime pine bark extract had anti-inflammatory effects on carrageenan-induced paw edema ( 16 ) and UV radiation ( 17 ) in animals and osteoarthritis ( 18 ) in humans.…”

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confidence: 99%

Effects of Flavangenol, an Extract of French Maritime Pine Bark on Collagen-Induced Arthritis in Rats

Tsubata

Takagaki

Hirano³

et al. 2011

J Nutr Sci Vitaminol

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Summary Flavangenol (FG), an extract of French maritime pine bark ( Pinus maritime ) mainly contains proanthocyanidin in oligomers. It has many physiological effects, including antioxidant and anti-atherosclerosis. In this study, we evaluated the effects of FG on rat collagen-induced arthritis, a model of human rheumatoid arthritis. The rats were fed with the diet of control, 0.3% FG, or 1% FG for 4 wk after the induction of arthritis. The FG diets, compared with the control diet, suppressed the increase in arthritic score and swelling of the paws in a dose-dependent manner. Histopathological examination revealed evidence that the 1% FG diet suppressed acute and chronic articular lesions in the rats. In addition, the FG diets (0.3% and 1%) suppressed the production of nitric oxide in the plasma of the rats. These results suggest that dietary FG has beneficial effects on collagen-induced arthritis in rats by inhibiting the acute and chronic inflammatory reactions.

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Pycnogenol supplementation reduces pain and stiffness and improves physical function in adults with knee osteoarthritis

Cited by 53 publications

References 17 publications

A Combination of Scutellaria Baicalensis and Acacia Catechu Extracts for Short-Term Symptomatic Relief of Joint Discomfort Associated with Osteoarthritis of the Knee

A Combination of Scutellaria Baicalensis and Acacia Catechu Extracts for Short-Term Symptomatic Relief of Joint Discomfort Associated with Osteoarthritis of the Knee

A review on biological, nutraceutical and clinical aspects of French maritime pine bark extract

Effects of Flavangenol, an Extract of French Maritime Pine Bark on Collagen-Induced Arthritis in Rats

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