Pycnogenol prevents peritoneal adhesions

Şahbaz, Ahmet; Aynıoğlu, Öner; Işık, Hatice; Gün, Banu Doğan; Cengil, Osman; Erol, Onur

doi:10.1007/s00404-015-3764-4

Cited by 5 publications

(7 citation statements)

References 34 publications

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“…Bleeding, cauterization, ischemia, infections, and conditions that may damage the peritoneum may trigger adhesions [5][6][7] . While numerous cells such as mesothelial cells, histiocytes, fibroblasts, and lymphocytes help in healing the injured area, they also play a role in the development of peritoneal adhesion [2][3][4][5] . It has been demonstrated that adhesions are often the result of improper healing due to injured peritoneal tissues associated with oxidative stress 2 .…”

Section: ■ Discussionmentioning

confidence: 99%

“…In our study, in addition to parameters such as fibrosis and inflammation, we performed GSTP-1, Glut Red, SOD-1, and CAT staining to immunohistochemically examine oxidative stress parameters in tissues. After postoperative days 5 and 7, these adhesive strips progressed to persistent fibrous adhesions 2,13 . It was also reported that hypoxia directly promotes the production of free oxygen radicals in tissues 2,14 .…”

Section: ■ Discussionmentioning

confidence: 99%

“…After postoperative days 5 and 7, these adhesive strips progressed to persistent fibrous adhesions 2,13 . It was also reported that hypoxia directly promotes the production of free oxygen radicals in tissues 2,14 . With the increase in the production of free oxygen radicals, the production of fibroblasts, tissue growth factor, vascular endothelial growth factor, and cytokines such as cyclooxygenase-2 that cause adhesions also increased 14,15 .…”

Section: ■ Discussionmentioning

confidence: 99%

“…The efficacy of vitamin E in the prevention of post-operative peritoneal adhesion has been reported 1,20,21 . Şahbaz et al 2 demonstrated that pycnogenol, which is an antioxidant, was effective for preventing peritoneal adhesion on postoperative day 10 owing to its anti-inflammatory and antioxidant effects. However, in contrast to the results of this study, we found that pycnogenol severely increased inflammation and resulted in foreign body reaction in some rats.…”

Section: ■ Discussionmentioning

confidence: 99%

“…The etiopathogenesis of peritoneal adhesions is not precisely known; however, inflammation, ischemia, and the presence of oxidative stress may be prevalent its etiopathogenesis 2,4-6 . Many types of steroids and non-steroidal antiinflammatory, fibrinolytic, and antioxidant agents as well as different techniques have been used to reduce or prevent the formation of postoperative peritoneal adhesions 2,5,7 . Additionally, conditions such as inflammation and infection that are secondary to intraabdominal operations may cause adhesions, whereas they may be responsible for the etiopathogenesis of lymphadenopathy that may develop secondary to inflammation 2,7 .…”

Section: ■ Introductionmentioning

confidence: 99%

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The effect of pycnogenol on lymphatic nodes and adhesion during in a peritoneal adhesion model in rats

Göret¹,

Göret

Kiraz

et al. 2018

Acta Cir. Bras.

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Purpose: To investigate the effects of pycnogenol on peritoneal adhesions and additionally to investigate the immunohistochemical effects of free oxygen radicals and reactive lymph nodes detected in the adhesive tissue that was sampled surrounding the cecum on intraabdominal adhesions. Methods: Twenty-seven Wistar Albino rats were divided into three groups. In group 1 (sham), laparotomy was performed and stitched up. In group 2 (control), after laparotomy was performed, punctate hemorrhage was induced by cecal abrasion in the cecum and each rat was intraperitoneally administered 2 cc of saline. In group 3 (experimental), after laparotomy was performed, punctate hemorrhage was induced by cecal abrasion in the cecum and each rat was intraperitoneally administered a sterile Pycnogenol derivative. The rats in all groups were re-laparotomized on postoperative day 7; samples were obtained from the peritoneal tissue surrounding the cecum, and the rats were sacrificed. Results: In group 3, there was a statistically significant difference in terms of inflammation, lymph node size, and free oxygen radicals; these parameters tended to increase. In terms of fibrosis evaluated using H&E and MT, there was no significant difference between groups 2 and 3. Conclusions: No positive outcomes indicating that pycnogenol reduces intra-abdominal adhesions were obtained. However, it caused severe inflammation in the tissue. Moreover, a significant increase in lymph node size was detected secondary to inflammation. Additionally, in immunohistochemical analyses conducted to detect oxidative stress, pycnogenol increased the production of free oxygen radicals in the tissue.

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Section: ■ Discussionmentioning

confidence: 99%

Section: ■ Discussionmentioning

confidence: 99%

Section: ■ Discussionmentioning

confidence: 99%

Section: ■ Discussionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The effect of pycnogenol on lymphatic nodes and adhesion during in a peritoneal adhesion model in rats

Göret¹,

Göret

Kiraz

et al. 2018

Acta Cir. Bras.

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A combination of hybrid polydopamine-human keratinocyte growth factor nanoparticles and sodium hyaluronate for the efficient prevention of postoperative abdominal adhesion formation

et al. 2022

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Preventive Effects of the Intestine Function Recovery Decoction, a Traditional Chinese Medicine, on Postoperative Intra‐Abdominal Adhesion Formation in a Rat Model

Zhou

Jia

Jiang

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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The intestine function recovery decoction (IFRD) is a traditional Chinese medicine that has been used for the treatment of adhesive intestinal obstruction. In this study, the preventative effects and probable mechanism of the IFRD were investigated in a rat model. We randomly assigned rats to five groups: normal, model, control, low dose IFRD, and high dose IFRD. In the animal model, the caecum wall and parietal peritoneum were abraded to induce intra-abdominal adhesion formation. Seven days after surgery, adhesion scores were assessed using a visual scoring system, and histopathological samples were examined. The levels of serum interleukin-6 (IL-6) and transforming growth factor beta-1 (TGF-β1) were analysed by an enzyme-linked immunosorbent assay (ELISA). The results showed that a high dose of IFRD reduced the grade of intra-abdominal adhesion in rats. Furthermore, the grades of inflammation, fibrosis, and neovascularization in the high dose IFRD group were significantly lower than those in the control group. The results indicate that the IFRD can prevent intra-abdominal adhesion formation in a rat model. These data suggest that the IFRD may be an effective antiadhesion agent.

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Pycnogenol prevents peritoneal adhesions

Abstract: Pycnogenol was found to be effective at preventing surgery-related adhesions in an animal model.

Cited by 5 publications

References 34 publications

The effect of pycnogenol on lymphatic nodes and adhesion during in a peritoneal adhesion model in rats

The effect of pycnogenol on lymphatic nodes and adhesion during in a peritoneal adhesion model in rats

A combination of hybrid polydopamine-human keratinocyte growth factor nanoparticles and sodium hyaluronate for the efficient prevention of postoperative abdominal adhesion formation

Preventive Effects of the Intestine Function Recovery Decoction, a Traditional Chinese Medicine, on Postoperative Intra‐Abdominal Adhesion Formation in a Rat Model

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