Pycnogenol ameliorates motor function and gene expressions of NF-ƙB and Nrf2 in a 6-hydroxydopamine-induced experimental model of Parkinson’s disease in male NMRI mice

Jafari, F Mahdavi; Goudarzvand, Mahdi; Hajikhani, Ramin; Qorbani, Mostafa; Solati, Jalal

doi:10.1007/s00210-022-02201-x

Cited by 5 publications

(7 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Group III, IV, and V rats were orally treated for 14 successive days with pycnogenol (10, 20, and 30 mg/kg, 1:9 mixture of DMSO and saline, 0.2 mL/rat, P.O., oral gavage) [69,73]. Then, the rats were administered a single dose of MTX (10 mg/kg, i.p.)…”

Section: Animals and Groupingmentioning

confidence: 99%

Protective Effect of Pycnogenol against Methotrexate-Induced Hepatic, Renal, and Cardiac Toxicity: An In Vivo Study

et al. 2022

View full text Add to dashboard Cite

Methotrexate (MTX) is one of the most commonly used chemotherapies for various types of cancer, including leukemia, breast cancer, hepatocarcinoma, and gastric cancers. However, the efficacy of MTX is frequently limited by serious side effects. Several studies have reported that the cytotoxic effect of MTX is not limited to cancer cells but can also affect normal tissues, leading to prospective damage to many organs. In the present study, we extensively investigated the molecular and microscopic basis of MTX-induced toxicity in different organs (liver, kidney, and heart) and explored the possible protective effect of pycnogenol, a polyphenolic component extracted from the bark of P. pinaster, to attenuate these effects. Biochemical analysis revealed that administration of MTX significantly reduced the function of the liver, kidney, and heart. Histological and immunohistochemical analysis indicated that MTX treatment caused damage to tissues of different organs. Interestingly, administration of pycnogenol (10, 20, and 30 mg/kg) significantly attenuated the deterioration effects of MTX on different organs in a dose-dependent manner, as demonstrated by biochemical and histological analysis. Our results reveal that pycnogenol successfully ameliorated oxidative damage and reduced toxicity, inflammatory response, and histological markers induced by methotrexate treatment. Taken together, this study provides solid evidence for the pharmacological application of pycnogenol to attenuate damage to different organs induced by MTX treatment.

show abstract

Section: Animals and Groupingmentioning

confidence: 99%

Protective Effect of Pycnogenol against Methotrexate-Induced Hepatic, Renal, and Cardiac Toxicity: An In Vivo Study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Extracts from pine bark have been reported that they have protective potential in experimental models of neurological diseases [15,17,18,33]. For example, a bark extract derived from Korean red pine (Pinus densiflora) protects neuronal PC-12 cells from hydrogen peroxide-induced cell death via reducing oxidative stresses and inhibiting enzymatic activities of cholinesterases [18].…”

Section: Discussionmentioning

confidence: 99%

“…For example, a bark extract derived from Korean red pine (Pinus densiflora) protects neuronal PC-12 cells from hydrogen peroxide-induced cell death via reducing oxidative stresses and inhibiting enzymatic activities of cholinesterases [18]. In a mouse model of Parkinson's disease induced by 6-hydroxydopamine, PYC administration alleviates catalepsy and increased expression of anti-inflammatory gene which is related with nuclear factor erythroid-2-related factor 2 [33]. In particular, in a gerbil model of IR, pretreatment with PYC displays an excellent antioxidative efficacy and protects hippocampal pyramidal neurons from IR injury [17].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Treatment with Pycnogenol® Attenuates Ischemic Brain Injury in Gerbils Focusing on Cognitive Impairment, Neuronal Death, BBB Leakage and Neuroinflammation in the Hippocampus

Lee¹,

Park²,

Shin³

et al. 2023

J. Integr. Neurosci.

View full text Add to dashboard Cite

Background: A gerbil model of ischemia and reperfusion (IR) injury in the forebrain has been developed for studies on mechanisms, prevention and therapeutic strategies of IR injury in the forebrain. Pycnogenol ® (PYC), a standardized extract of French maritime pine tree (Pinus pinaster Aiton) has been exploited as an additive for dietary supplement. In the present study, we investigated the neuroprotective effects of post-treatment with PYC and its therapeutic mechanisms in gerbils. Methods: The gerbils were given sham and IR operation and intraperitoneally injected with vehicle and Pycnogenol ® (25, 50 and 100 mg/kg, respectively) immediately, at 24 hours and 48 hours after sham and IR operation. Through 8-arm radial maze test and passive avoidance test, each spatial memory and short-term memory function was assessed. To examine the neuroprotection of Pycnogenol ® , we conducted cresyl violet staining, immunohistochemistry for neuronal nuclei, and Fluoro-Jade B histofluorescence. Moreover, we carried out immunohistochemistry for immunoglobulin G (IgG) to investigate blood-brain barrier (BBB) leakage and interleukin-1β (IL-1β) to examine change in pro-inflammatory cytokine. Results: We found that IR-induced memory deficits were significantly ameliorated when 100 mg/kg Pycnogenol ® was treated. In addition, treatment with 100 mg/kg Pycnogenol ® , not 25 mg/kg nor 50 mg/kg, conferred neuroprotective effect against IR injury. For its mechanisms, we found that 100 mg/kg Pycnogenol ® significantly reduced BBB leakage and inhibited the expression of IL-1β. Conclusions: Therapeutic treatment (post-treatment) with Pycnogenol ® after IR effectively attenuated ischemic brain injury in gerbils. Based on these results, we suggest that PYC can be employed as an important material for ischemic drugs.

show abstract

“…Moreover, PYC could prevent DNA damage in hepatocytes, which is stimulated by sepsis (Taner et al, 2014) or ischemia/reperfusion oxidative damage (Tokaç et al, 2017). In addition, PYC have antioxidative and antiinflammatory effects by increasing the expression of the Nrf2 (Nuclear factor (NF)‐E2‐related factor‐2 (Nrf2)) gene which is a key transcription factor in experimental model studies (Jafari, Goudarzvand, Hajikhani, Qorbani, & Solati, 2022; Meng et al, 2017). However, further trials are required to clarify its mechanism.…”

Section: Methodsmentioning

confidence: 99%

“…gene which is a key transcription factor in experimental model studies (Jafari, Goudarzvand, Hajikhani, Qorbani, & Solati, 2022;Meng et al, 2017). However, further trials are required to clarify its mechanism.…”

Section: Antioxidant Effects Of Pyc On Hepatic Indicesmentioning

confidence: 99%

The role of Pycnogenol in the control of inflammation and oxidative stress in chronic diseases: Molecular aspects

Nattagh‐Eshtivani

Gheflati

Barghchi

et al. 2022

Phytotherapy Research

View full text Add to dashboard Cite

The prevalence of chronic diseases has increased significantly with the rising trend of sedentary lifestyles, reduced physical activity, and dietary modifications in recent decades. Inflammation and oxidative stress play a key role in the pathophysiology of several chronic diseases, such as type II diabetes, cardiovascular diseases, and hepatic conditions. Therefore, reducing inflammation and oxidative stress may be beneficial in the prevention and treatment of various chronic disorders. Since chronic diseases are not completely curable, various methods have been proposed for their control. Complementary therapies and the use of natural antioxidant and antiinflammatory compounds are among these novel approaches. Pycnogenol (PYC) is a natural compound that could control inflammation and oxidative stress. Furthermore, some previous studies have shown that PYC could effectively reduce inflammation through signaling the downstream of insulin receptors, inhibiting the phosphorylation of the serine residues of insulin receptor substrate‐1, reducing pro‐inflammatory cytokines and oxidative stress indices through the stimulation of antioxidant pathways, increasing free radical scavenging activities, preventing lipid peroxidation, and protecting the erythrocytes in glucose‐6‐phosphate dehydrogenase‐deficient individuals, although these effects have not been fully proved. The present study aimed to comprehensively review the evidence concerning the positive physiological and pharmacological properties of PYC, with an emphasis on the therapeutic potential of this natural component for enhancing human health.

show abstract

Pycnogenol ameliorates motor function and gene expressions of NF-ƙB and Nrf2 in a 6-hydroxydopamine-induced experimental model of Parkinson’s disease in male NMRI mice

Cited by 5 publications

References 32 publications

Protective Effect of Pycnogenol against Methotrexate-Induced Hepatic, Renal, and Cardiac Toxicity: An In Vivo Study

Protective Effect of Pycnogenol against Methotrexate-Induced Hepatic, Renal, and Cardiac Toxicity: An In Vivo Study

Therapeutic Treatment with Pycnogenol® Attenuates Ischemic Brain Injury in Gerbils Focusing on Cognitive Impairment, Neuronal Death, BBB Leakage and Neuroinflammation in the Hippocampus

The role of Pycnogenol in the control of inflammation and oxidative stress in chronic diseases: Molecular aspects

Contact Info

Product

Resources

About