Abstract:IntroductionSeveral studies have highlighted the risks in patients with a flare of colitis and concomitant Clostridium difficile infection: including increased mortality and increased rates of colectomy in patients with ulcerative colitis (UC). Infection control policies, including antibiotic prescribing, have had an impact on rates of Clostridium difficile associated diarrhoea (CDAD) in the general in-patient population but rates of CDAD in inflammatory bowel disease (IBD) have been reported to be as high as … Show more
“…A few studies have demonstrated an increase risk of colectomy with CDI in IBD patients, while others have either shown an inverse relationship or no effect at all . A recent meta‐analysis concluded that CDI was associated with higher surgical rates in ulcerative colitis (UC); however, multiple key studies were not analysed, including several recently published studies . Moreover, substantial variability in follow‐up period between studies limited the comparability of studies contained in this review.…”
Based on 12 observational studies with at least moderate quality, Clostridium difficile infection appears to increase colectomy risk in IBD in the long- but not short- term.
“…A few studies have demonstrated an increase risk of colectomy with CDI in IBD patients, while others have either shown an inverse relationship or no effect at all . A recent meta‐analysis concluded that CDI was associated with higher surgical rates in ulcerative colitis (UC); however, multiple key studies were not analysed, including several recently published studies . Moreover, substantial variability in follow‐up period between studies limited the comparability of studies contained in this review.…”
Based on 12 observational studies with at least moderate quality, Clostridium difficile infection appears to increase colectomy risk in IBD in the long- but not short- term.
Colonic involvement, biologic and antibiotic use appear to be risk factors associated with CDI amongst IBD patients. CDI is associated with increased short and long-term mortality.
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