PWE-012 Small bowel ultrasound in crohn’s disease- outcomes in a district general hospital

Abstract

over 48 hours increased the epithelial cell proliferation rate by up to 56% in Caco-2 (p<0.01) and 42% in HT-29 (p<0.001) cells. Conclusion Our data demonstrates that IL-27 enhances epithelial barrier wound healing. Gene expression data suggests that cell-cell adhesion is enhanced through increased E-cadherin expression, with a reduction in permeability through decreased expression of claudin-2 (pore forming) and increase in claudin-4 (pore closing). Tight junction function is enhanced through increased expression of occludin and tight junctional protein-1. Further studies will define the IL-27 driven permeability related protein expression profile and impact on functional permeability in organoids and whether IL-27 is a potential new treatment for IBD.