PW02-035 - A role for thermo-TRP channels in innate immunity?

Stoffels, Monique; Remijn, Thijs; Elders, LM; Koning, Heleen D. de; Meer, JW van der; Simon, Anna

doi:10.1186/1546-0096-11-s1-a176

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“…Increased transcription of IL-1α, IL-1β, IL-6, and IL-8 cytokine genes in human lung epithelial cells through activation of a TRPM8 variant by exposure to cold temperatures has been reported [ 43 ]. Moreover, in a recent abstract presented at the ISSAID Congress 2013 by Stoffels and colleagues it has been hypothesized that in vivo cold exposure could result in a modulated inflammatory response through activation of temperature-sensitive ion channels [ 44 ]. Thus, exposure to cold, or ex vivo stimulation of peripheral blood mononuclear cells with menthol, a TRPM8 agonist, induces an exaggerated (local and systemic) cytokine inflammatory response, as evaluated at protein level by enzyme-linked immunosorbent assays in several human-derived cell lines, primary cells and skin biopsies.…”

Section: The Trp Receptors Recognize Environmental Exogenous and Endomentioning

confidence: 99%

“…Thus, exposure to cold, or ex vivo stimulation of peripheral blood mononuclear cells with menthol, a TRPM8 agonist, induces an exaggerated (local and systemic) cytokine inflammatory response, as evaluated at protein level by enzyme-linked immunosorbent assays in several human-derived cell lines, primary cells and skin biopsies. Activation of the temperature-sensitive TRPM8 channel via TLRs results in an enhanced IL-1β secretion and, likely, NLRP3 inflammasome formation [ 44 ].…”

Section: The Trp Receptors Recognize Environmental Exogenous and Endomentioning

confidence: 99%

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Danger- and pathogen-associated molecular patterns recognition by pattern-recognition receptors and ion channels of the transient receptor potential family triggers the inflammasome activation in immune cells and sensory neurons

Santoni

Cardinali

Morelli

et al. 2015

J Neuroinflammation

139

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An increasing number of studies show that the activation of the innate immune system and inflammatory mechanisms play an important role in the pathogenesis of numerous diseases. The innate immune system is present in almost all multicellular organisms and its activation occurs in response to pathogens or tissue injury via pattern-recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs). Intracellular pathways, linking immune and inflammatory response to ion channel expression and function, have been recently identified. Among ion channels, the transient receptor potential (TRP) channels are a major family of non-selective cation-permeable channels that function as polymodal cellular sensors involved in many physiological and pathological processes.In this review, we summarize current knowledge of interactions between immune cells and PRRs and ion channels of TRP families with PAMPs and DAMPs to provide new insights into the pathogenesis of inflammatory diseases. TRP channels have been found to interfere with innate immunity via both nuclear factor-kB and procaspase-1 activation to generate the mature caspase-1 that cleaves pro-interleukin-1β cytokine into the mature interleukin-1β.Sensory neurons are also adapted to recognize dangers by virtue of their sensitivity to intense mechanical, thermal and irritant chemical stimuli. As immune cells, they possess many of the same molecular recognition pathways for danger. Thus, they express PRRs including Toll-like receptors 3, 4, 7, and 9, and stimulation by Toll-like receptor ligands leads to induction of inward currents and sensitization in TRPs. In addition, the expression of inflammasomes in neurons and the involvement of TRPs in central nervous system diseases strongly support a role of TRPs in inflammasome-mediated neurodegenerative pathologies. This field is still at its beginning and further studies may be required.Overall, these studies highlight the therapeutic potential of targeting the inflammasomes in proinflammatory, autoinflammatory and metabolic disorders associated with undesirable activation of the inflammasome by using specific TRP antagonists, anti-human TRP monoclonal antibody or different molecules able to abrogate the TRP channel-mediated inflammatory signals.

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Section: The Trp Receptors Recognize Environmental Exogenous and Endomentioning

confidence: 99%

Section: The Trp Receptors Recognize Environmental Exogenous and Endomentioning

confidence: 99%

Danger- and pathogen-associated molecular patterns recognition by pattern-recognition receptors and ion channels of the transient receptor potential family triggers the inflammasome activation in immune cells and sensory neurons

Santoni

Cardinali

Morelli

et al. 2015

J Neuroinflammation

139

View full text Add to dashboard Cite

show abstract

PW02-035 - A role for thermo-TRP channels in innate immunity?

Cited by 1 publication

References 0 publications

Danger- and pathogen-associated molecular patterns recognition by pattern-recognition receptors and ion channels of the transient receptor potential family triggers the inflammasome activation in immune cells and sensory neurons

Danger- and pathogen-associated molecular patterns recognition by pattern-recognition receptors and ion channels of the transient receptor potential family triggers the inflammasome activation in immune cells and sensory neurons

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