PVP‐co‐DMAEMA as Novel Polymeric Coating Material for Probiotic Supplements Delivery

Abstract

The paper investigates the use of poly(1‐vinylpyrrolidone‐co‐2‐dimethylaminoethylmetacrilate) (PVP‐co‐DMAEMA) as a novel coating agent in the preparation of alginate‐based microcapsule for the supplement delivery of probiotics. Probiotic Lactobacillus plantarum is used to study the viability of the encapsulated bacterium when exposed to conditions simulating the gastrointestinal tract and industrial process. Results demonstrate that the PVP‐co‐DMAEMA polymer constitutes a pH‐responsive coating suitable for probiotic supplement delivery.

Biopolymer‐Based Multilayer Microparticles for Probiotic Delivery to Colon

“…[90] While chitosan remains one of the most used shell materials, it may result in allergic or immunomodulatory effects in some consumers. As a result, coating of alginate microcapsules with more biocompatible polycations such as buttermilk protein, [91] zein, [63] and poly(1-vinylpyrrolidone-co-2-dimethylaminoethyl methacrylate) [92] emerged as alternative options with promising results. Alginate microparticles can also be coated with polyanions, [93] or neutrally charged Fluorescence images showing retention of each variation of microcapsules on porcine gastric mucosa after the indicated time of washing with simulated gastric fluid (0.2% w/v NaCl, pH 2).…”