PUVA Treatment of Alopecia Areata

Claudy, A; Gagnaire, D

doi:10.1001/archderm.1983.01650360021007

Cited by 64 publications

(25 citation statements)

References 13 publications

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“…Although our results could appear to be unsatisfactory we want to point out that we considered as a success only patients who had a complete hair regrowth after treatment. Our percentage of complete regrowth is therefore comparable with the results obtained by other authors [6,12,[13][14][15][16][17][18][19] in the treatment of severe AA. The effectiveness of Thymopentin in AA is possibly related to the effects of this drug on the aberrant T-cell-mediated immunity as sociated with this disease.…”

Section: Discussionsupporting

confidence: 91%

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Thymopentin in the Treatment of Severe Alopecia areata

1988

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Since alopecia areata might be due to an aberrant T-cell-mediated immunity, the purpose of our study was to compare the results obtained with Thymopentin to those of topical sensitizing therapies, such as squaric acid dibutylester or diphencyprone. Statistical analysis showed no differences between the results obtained with these two therapies. Therefore, Thymopentin can be considered to be a new therapeutic agent which, like the classic topical drugs squaric acid dibutylester or diphencyprone, has immunoreactive properties and might provide some hope to patients with severe alopecia areata.

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Section: Discussionsupporting

confidence: 91%

“…This hypo thesis is further supported by the fact that in AA hair regrowth can be induced by differ ent therapies which all act on the T-cellmediated immunity [6][7][8][9].…”

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confidence: 90%

Thymopentin in the Treatment of Severe Alopecia areata

1988

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“…topical anthralin or PUVA seem to be comparable alternatives, whereas a complete hair regrowth is rarely achieved using topical minoxidil in severe alopecia [18][19][20][21][22].…”

Section: Treatment: Is It Worthwhile?mentioning

confidence: 99%

Alopecia areata: More on Pathogenesis and Therapy

Tosti

1989

Dermatology

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“…The reports about the efficacy of PUVA therapy are conflicting. Several studies have shown low response rates of PUVA therapy [60,61], while others have shown good response rates [62,63]. PUVA therapy is thought to eradicate the mononuclear cell infiltrate, surrounding the hair follicle responsible for the disease [16].…”

Section: Photochemotherapymentioning

confidence: 99%

Alopecia Areata

Engın¹,

Oba²,

Tüzün³

2017

Hair and Scalp Disorders

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Alopecia areata is an organ-specific autoimmune disease targeting hair follicles. It causes nonscarring hair loss. The prevalence rate of the disease is approximately 1 in 1000 people worldwide. The condition is most commonly seen as circular areas of hair loss, but it may sometimes be as extensive as to involve the whole scalp or whole body. The complex pathophysiology of alopecia areata involves an autoimmune basis. Association of alopecia areata with other autoimmune diseases, such as thyroiditis and vitiligo, and the good response of patients to immunosuppressive treatment support an autoimmune etiology. Although some poor prognostic signs are defined, the course of the disease is unpredictable and the response to treatment can be variable. To date, there are neither preventive nor curative measures to deal with the condition. First-line therapy for patchy disease is topical and intralesional steroids, whereas extensive disease is conventionally managed with immunotherapy. New treatment agents, such as excimer laser, low-dose recombinant interleukin 2, Janus kinase inhibitors, and simvastatin/ezetimibe, are promising.

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PUVA Treatment of Alopecia Areata

Cited by 64 publications

References 13 publications

Thymopentin in the Treatment of Severe Alopecia areata

Thymopentin in the Treatment of Severe Alopecia areata

Alopecia areata: More on Pathogenesis and Therapy

Alopecia Areata

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