PUVA (psoralen+UVA) photochemotherapy: processes triggered in the cells

Signalling Oxidative Stress in Saccharomyces cerevisiae

“…Another interpretation is that oxygen reacts with 8-MOP and components of the cell membrane leading to lipid peroxidation. This would be the starting point to signal to the CWI (Dall'Acqua & Martelli, 1991;Zarebska, 2000;Dardalhon et al, 2009) In a recent report, Bandyopadhyay et al (2010) have used a new methodological approach called differential epistasis mapping. By doing so they have also found a genetic interaction between Slt2 and DNA repair genes.…”

Design, synthesis and docking studies of new furobenzopyranones and pyranobenzopyranones as photoreagent towards DNA and as antimicrobial agents

“…In this study the compounds (2)(3)(4)(5)(6)(7)(9)(10)(11)(12)(13)(14) were screened for antimicrobial and photosensitizing activity by the disc diffusion method [47] compared with reference compound xanthotoxin, which can be clinically investigated. The test organism used was Bacillus subtilis.…”

“…Extensive photochemical and photobiological studies have been performed mainly on two series of furobenzopyranones, that is psoralens (linear furobenzopyrones) [13,14] and, angelicins (angular furobenzopyranones) [15][16][17][18][19]. In addition, new DNA monofunctional furobenzopyranones as 6-carbethoxy analogues [20], furobenzopyranones with modified annulations geometry [21] as well as pyridopsoralens [22][23][24], azapsoralens [25], furoquinolinones [26], thienoquinolinones [27] have been prepared.…”

Repair efficiency and PUVA therapeutic response variation in patients with vitiligo

“…It was reported that, psoralens render not only cytostatic, but also immunosuppressive effect (Zarebska et al, 2000).…”