The emergence of legislation regulating the employment of children in the textile factories of Great Britain in the mid-19th century inaugurated a formal link between economic and social development. It is regarded as one of the first attempts at crafting legal social protection (Marvel, 1977), backed by administrative efforts by the state to enforce it. 1 More than 150 years have passed and labour administration is still expected to play an important role for world development. Labour administration bodies are clearly implicated in the promotion of sustained, inclusive and sustainable economic growth, full and productive employment and decent work for all -the United Nations Sustainable Development Goal (SDG) 8. 2 However, the fulfilment of such expectations will require significant transformations in the way labour regulation systems operate. There are good reasons for believing that methods of enforcement that were effective in the past will not be sufficient to meet new challenges related to changes in the organization and location of work. This chapter discusses potential ways of meeting the emerging challenges and calls for a rethinking of the governance of labour regulation and enforcement.Regulating economic forces and protecting workers are long-standing challenges. In the beginning of the 20th century, it entailed the passing of national labour laws and the setting up of the administrative apparatuses responsible for enforcing such laws (Arthurs, 1980;Field, 1990;Richthofen, 2002). By 1910, official bodies for supervising the application of labour laws had been set up in 22 European countries (Wallin, 1969), in addition to similar developments in the Americas (Canada, Argentina, Chile and Uruguay), Japan and many more countries in the following decades (Jatobá, 2002;Ruiz, 2009aRuiz, , 2009b.