Putative Contribution of 8-Aminoquinolines to Preventing Recrudescence of Malaria

Markus, Miles B.

doi:10.3390/tropicalmed8050278

Cited by 3 publications

(2 citation statements)

References 108 publications

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“…The repellent advised comprises 20-35% N,N-Diethyl-meta-toluamide (DEET). If you are going to be outside at night, wear long-sleeved apparel and long pants [47,48].…”

Section: Preventionmentioning

confidence: 99%

A Systematic Review on Malaria Disease and Its Treatments Focus on Artemether Drug

PHALAK,

BODKE,

BODKE

et al. 2024

Int J Curr Pharm Sci

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Malaria is one of the infectious illnesses of the highest scientific significance and importance to international health organizations. Plasmodium falciparum, the parasite responsible for a highly severe form of the disease in Africa, has traditionally received the most attention. However, in the last two decades, the Plasmodium vivax parasite, which is linked to a large number of cases in Latin America, the Middle East, South and Southeast Asia, the Horn of Africa, and Oceania, has sparked enormous interest, owing to published evidence that it can cause severe malaria, among other things. Malaria is a worldwide public health problem, with a saw 247 million cases recorded in 2021. African countries accounted for approximately 94% of all reported cases. So far, over 200 distinct varieties of protozoa have been discovered and identified, with at least 13 of them being pathogenic to humans. The malaria parasite's life cycle is a complex process involving a mosquito with the species Anopheles and a vertebrate host. Artemether is a lipid-soluble artemisinin derivative. It is available in both oral and intramuscular forms. It is also available as a fixed-dose formulation with lumefantrine. Artemether-lumefantrine is one of the ACTs authorized by the WHO and is being used by the majority of countries transitioning from less effective medications to ACTs. However, the emergence of antimalarial medication resistance poses a significant challenge to malaria control. It works by killing the pathogenic organisms responsible for malaria. It is known as an antimalarial medication, and it is more effective than quinine therapies.

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“…The repellent advised comprises 20-35% N,N-Diethyl-meta-toluamide (DEET). If you are going to be outside at night, wear long-sleeved apparel and long pants [47,48].…”

Section: Preventionmentioning

confidence: 99%

A Systematic Review on Malaria Disease and Its Treatments Focus on Artemether Drug

PHALAK,

BODKE,

BODKE

et al. 2024

Int J Curr Pharm Sci

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“…Later in evolution, further adaptation for prolonged persistence in the liver before fresh blood stage infection (‘long latency phenotype’) may have enabled the parasite to survive in temperate areas with shorter mosquito transmission seasons [ 14 ]. In addition to relapse infections resulting from hypnozoite activation, it has been suggested that P. vivax parasites accumulating in the spleen and bone marrow may serve as an important reservoir that might be the source of recrudescence, contributing to chronic malaria [ 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Transfection Models to Investigate Plasmodium vivax-Type Dormant Liver Stage Parasites

Voorberg-van der Wel,

Zeeman,

Kocken

2023

Pathogens

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Plasmodium vivax causes the second highest number of malaria morbidity and mortality cases in humans. Several biological traits of this parasite species, including the formation of dormant stages (hypnozoites) that persist inside the liver for prolonged periods of time, present an obstacle for intervention measures and create a barrier for the elimination of malaria. Research into the biology of hypnozoites requires efficient systems for parasite transmission, liver stage cultivation and genetic modification. However, P. vivax research is hampered by the lack of an in vitro blood stage culture system, rendering it reliant on in vivo-derived, mainly patient, material for transmission and liver stage culture. This has also resulted in limited capability for genetic modification, creating a bottleneck in investigations into the mechanisms underlying the persistence of the parasite inside the liver. This bottleneck can be overcome through optimal use of the closely related and experimentally more amenable nonhuman primate (NHP) parasite, Plasmodium cynomolgi, as a model system. In this review, we discuss the genetic modification tools and liver stage cultivation platforms available for studying P. vivax persistent stages and highlight how their combined use may advance our understanding of hypnozoite biology.

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The biology and pathogenesis of vivax malaria

Anstey,

Tham,

Shanks

et al. 2024

Trends in Parasitology

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Putative Contribution of 8-Aminoquinolines to Preventing Recrudescence of Malaria

Cited by 3 publications

References 108 publications

A Systematic Review on Malaria Disease and Its Treatments Focus on Artemether Drug

A Systematic Review on Malaria Disease and Its Treatments Focus on Artemether Drug

Transfection Models to Investigate Plasmodium vivax-Type Dormant Liver Stage Parasites

The biology and pathogenesis of vivax malaria

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