Putaminal diffusivity changes correlates with motor progression in Parkinson's disease on 6-year follow-up

Chan, Ling‐Ling; Ng, Kia-Min; Yeoh, Chooi-Sum; Li, H.H.; Rumpel, Helmut; Tan, Eng‐King

doi:10.1016/j.parkreldis.2015.10.374

Cited by 1 publication

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“…Some studies also focused on subcortical, cortical, white matter, cerebellar regions, and reported significant alterations in PD in many regions including the substantia nigra, caudate nucleus, putamen, globus pallidus, olfactory cortex and white matter of the corpus callosum [10]. Putaminal diffusivity correlates with disease progression in Parkinson's Disease which shows involvement in brain grey matter [11].…”

Section: Introductionmentioning

confidence: 99%

A Diffusion tensor imaging study to compare normative fractional anisotropy values with patients suffering from Parkinson’s disease in the brain grey and white matter

Kotian

Prakashini

Nair

2020

Preprint

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Background: Diffusion tensor imaging (DTI) appears as a sensitive method to study Parkinsons disease (PD) pathophysiology and severity. Fractional anisotropy (FA) value is one of the scalar derivatives of DTI used to find out anisotropy within a voxel in a tissue and used for determining white matter integrity in aging and neurodegenerative diseases. We studied DTI derived FA in early PD subjects as their routine MRI scans were normal. Methods: 40 patients with early PD and 40 healthy controls were employed to evaluate changes in microstructural white and grey matter in the brains using DTI derived FA values. Comparison of FA values in the brains white and grey matter of patients with PD and age matched controls at the corpus callosum, centrum semiovale, pons, putamen, caudate nucleus, substantia nigra, cerebral peduncles and cerebellar peduncles, was done using a region of interest (ROI) technique, with b-value 1000s/mm2 and TE=100 milliseconds using 1.5T MRI system. Results: PD patients showed differences in FA values in both the grey and white matter areas of the brains compared to healthy controls. Our study revealed the presence of damage in the substantia nigra, corpus callosum, putamen and cerebral peduncles mainly in the PD group. Conclusion: Our findings indicate that DTI and region of interest (ROI) methods can be used in patients with early PD to study microstructural alterations mainly in the substantia nigra, putamen and corpus callosum. Keywords: Fractional anisotropy, diffusion tensor imaging, Parkinsons disease, magnetic resonance imaging, neuroimaging.

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Section: Introductionmentioning

confidence: 99%