Pustular psoriasis induced by infliximab

Occurrence of Pustular Psoriasis after Treatment of Crohn Disease with Infliximab

“…More than one hundred cases were reported in a 2008 review, with fifty‐three percent of affected persons taking infliximab prior to their psoriatic flare (1). Similar eruptions have been noted in each of the three available forms of TNFα‐antagonists (1–5). No predilection for age, sex, race, or underlying disease has been determined (1,2).…”

“…In the majority of reported cases, cutaneous lesions are managed adequately with topical corticosteroids while continuing anti‐TNFα therapy (1,2,4). Some authors did report more recalcitrant incidents requiring cessation of the TNFα‐inhibitor (1).…”

Generalized pustular psoriasis of pregnancy treated with infliximab

“…There are no reports of infliximab use in GPPP but it has been used successfully for pustular psoriasis of von Zumbusch 3 . Paradoxically, it has also been reported to induce pustular psoriasis 7 . Whether infliximab would have been safe to use during gestation in this case is uncertain.…”

Infliximab: Efficacy in psoriasis

“…[54] Worsening of psoriasis after infliximab Paradoxical activation of psoriasis, including pustular psoriasis and palmoplantar pustulosis, with infliximab treatment has been occasionally observed in adults and in children. [55][56][57][58][59][60] Mössner et al [57] reported 5 patients with chronic plaque-type psoriasis who developed palmoplantar pustulosis during or after discontinuation of infliximab therapy. In two of the five cases, manifestation of palmoplantar pustulosis was not accompanied by worsening of plaque-type psoriasis.…”