Pustular eruptions following administration of cefazolin: A possible interaction with methyldopa

Stough, Dow B.; Guin, Jere D.; Baker, Glen F.; Haynie, Laura S.

doi:10.1016/s0190-9622(87)80416-4

Cited by 23 publications

(3 citation statements)

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“…They presented with unusual distributions and varying histologic findings in regard to the presence or absence of spongiosis and acantholysis. These cases involved isoniazid [44], gefitinib [45], paclitaxel [46], cefazolin [47], and amoxicillin [48]. A case of subcorneal pustules induced by dapsone and quinidine in a patient with known SPD has also been reported [49].…”

Section: Drug Reactionsmentioning

confidence: 99%

Subcorneal Pustular Dermatosis: A Review of 30 Years of Progress

2016

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Subcorneal pustular dermatosis (SPD), also known as Sneddon-Wilkinson disease, is a rare, benign yet relapsing pustular dermatosis. Its incidence and prevalence have not been well studied. It characteristically presents as hypopyon pustules on the trunk and intertriginous areas of the body. SPD is similar to two other disease entities. Both SPD-type immunoglobulin (Ig)-A pemphigus and annular pustular psoriasis clinically and histologically present similarly to SPD. Immunologic studies separate SPD-type IgA pemphigus from SPD and pustular psoriasis. However, there is still an unclear designation as to whether SPD is its own entity distinct from pustular psoriasis, as the once thought characteristic histologic picture of psoriasis does not hold true for pustular psoriasis. SPD has been reported to occur in association with several neoplastic, immunologic, and inflammatory conditions. Dapsone remains the first-line treatment for SPD, although dapsone-resistant cases have been increasingly reported. Other therapies have been used singly or as adjunctive therapy with success, such as corticosteroids, immunosuppressive agents, tumor necrosis factor inhibitors, and ultraviolet light therapy. This article provides a review of the last 30 years of available literature, with a focus on successful treatment options and a suggestion for reappraisal of the classification of SPD.

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Section: Drug Reactionsmentioning

confidence: 99%

Subcorneal Pustular Dermatosis: A Review of 30 Years of Progress

2016

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“…To date, antibacterials arc the main drug class implica ted in the etiology of AGEP, and arc nearly restricted to (3-lactams, especially ampicillin [2,3], amoxicillin [3,4], cephalosporins [5][6][7][8] or imipenem [9], and to macrolides [10]. On the other hand, nonant ¡bacterial drugs arc rarely considered as responsible for AGEP.…”

Section: Discussionmentioning

confidence: 99%

“…In our case, the eruption began 10 days after the introduction of nadoxolol and 4 days after stopping roxith romycin. Interestingly, in the previously reported case by Plantin et al [3], the time interval between the first nadoxolol administration and the onset of AGEP was long (several weeks), whereas it is clearly established that this time interval is generally very short (a few hours to 2 days) in AGEP following antibiotic intake [2][3][4][5][6][7][8][9][10], This was a deciding argument for implicating nadoxolol, and not roxithromycin, in our AGEP case. Based upon the current methodology used in France for assessing drug reaction [13], the causality link with nadoxolol was prob able.…”

Section: Discussionmentioning

confidence: 99%

Acute Generalized Exanthematic Pustulosis

Bernard

Bédane²,

Catanzano³

et al. 1991

Dermatology

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A 74-year-old woman developed a generalized pustular dermatosis with erythema-multiforme-like and vesiculobullous lesions 10 days after beginning a treatment by nadoxolol. Despite the clinical polymorphism of the eruption, histology constantly revealed the presence of subcorneal pustules, even within the epidermis overlying subepidermal bullae. The eruption spontaneously healed after discontinuation of nadoxolol.

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Acute Generalized Exanthematous Pustulosis

Roujeau¹

1991

Arch Dermatol

447

201

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We retrospectively analyzed 63 observations collected in nine French departments of dermatology of an acute pustular dermatosis, recently named in the French literature acute generalized exanthematous pustulosis (AGEP). Even though 11 of these cases occurred in patients with a history of psoriasis, AGEP appeared distinct from pustular psoriasis based on several slight pathologic differences, drug induction in most cases, and a more acute course of fever and pustulosis, with rapid spontaneous healing. We, therefore, suggest that AGEP is a reaction pattern, perhaps favored by a "psoriatic background." The most frequent causes of AGEP seem to be drug reactions, acute infections with enteroviruses, and hypersensitivity to mercury. With 55 (87%) of 63 cases attributed to drugs in this series, AGEP should be added to the list of cutaneous adverse drug reactions. Among drug-induced skin eruptions, AGEP is remarkable by its short time to onset after the administration of the suspected drug (less than 24 hours in half of our cases) and the great predominance (80%) of antibiotics as causative agents. It is suggested that some cases previously reported as "drug-induced pustular psoriasis" were in fact AGEP.

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Pustular eruptions following administration of cefazolin: A possible interaction with methyldopa

Cited by 23 publications

References 1 publication

Subcorneal Pustular Dermatosis: A Review of 30 Years of Progress

Subcorneal Pustular Dermatosis: A Review of 30 Years of Progress

Acute Generalized Exanthematic Pustulosis

Acute Generalized Exanthematous Pustulosis

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