Pushing the boundaries of VCD spectroscopy in natural product chemistry

Abstract

Vibrational circular dichroism (VCD) is one of the most powerful techniques to assess stereochemistry of chiral molecules in solution state. The need for quantum chemical calculations to interpret experimental data,...

Chiral nanomaterial-based approaches for diagnosis and treatment of protein-aggregated neurodiseases: current status and future opportunities

“…Thus far, many different variants of CD such as vibrational CD (VCD), magnetic CD (MCD), and fluorescence CD have been explored for measuring chirality. [78][79][80] The classical CD measurement gives results in molar ellipticity (mdeg), whereas modern chirality measurement from nanomaterials gives CD measurement in terms of Kuhn's dissymmetry unit g calculated using eqn (1): 81…”

“…Thus far, many different variants of CD such as vibrational CD (VCD), magnetic CD (MCD), and fluorescence CD have been explored for measuring chirality. 78–80 The classical CD measurement gives results in molar ellipticity (mdeg), whereas modern chirality measurement from nanomaterials gives CD measurement in terms of Kuhn's dissymmetry unit g calculated using eqn (1): 81 g = 2( I lcp − I rcp / I lcp + I rcp )where lcp corresponds to left-handed circularly polarized light and rcp corresponds to right-handed circularly polarized light. Apart from the conventional CD measurement, recent innovations in the areas of second harmonic generation (SHG) were done for characterizing the chirality of carbon nanomaterials.…”

Vibrational circular dichroism spectroscopy in the C–D, XY, and XYZ stretching region

“…Furthermore, the usefulness of VCD spectroscopy has been fueled by new theoretical approaches to better interpret spectra 3 and by newly established spectra–structures relationship. 4…”