Push-pull osmotic pump for zero order delivery of lithium carbonate: Development and<i>in vitro</i>characterization

Patel, Vineetkumar; Chudasama, Arpan; Nivsarkar, Manish; Vasu, Kamala K.; Shishoo, C. J.

doi:10.3109/10837450.2010.542577

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…However, these nano-drugs also need to be investigated for cancer treatment. To avoid fluctuations in the plasma concentration of lithium, a push-pull osmotic pump was developed for lithium carbonate delivery, to maintain Li + ion at therapeutic levels [ 196 ]. Cellular death results from apoptotic and necrotic processes that have an anticancer effect [ 197 ], but apoptosis rather than necrosis is the accepted pathway of cellular death under the immune system control [ 198 ].…”

Section: Trends In the Administration Of Lithiummentioning

confidence: 99%

Lithium: A Promising Anticancer Agent

Villegas-Vázquez

Quintas-Granados

Cortés

et al. 2023

Life

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Lithium is a therapeutic cation used to treat bipolar disorders but also has some important features as an anti-cancer agent. In this review, we provide a general overview of lithium, from its transport into cells, to its innovative administration forms, and based on genomic, transcriptomic, and proteomic data. Lithium formulations such as lithium acetoacetate (LiAcAc), lithium chloride (LiCl), lithium citrate (Li3C6H5O7), and lithium carbonate (Li2CO3) induce apoptosis, autophagy, and inhibition of tumor growth and also participate in the regulation of tumor proliferation, tumor invasion, and metastasis and cell cycle arrest. Moreover, lithium is synergistic with standard cancer therapies, enhancing their anti-tumor effects. In addition, lithium has a neuroprotective role in cancer patients, by improving their quality of life. Interestingly, nano-sized lithium enhances its anti-tumor activities and protects vital organs from the damage caused by lipid peroxidation during tumor development. However, these potential therapeutic activities of lithium depend on various factors, such as the nature and aggressiveness of the tumor, the type of lithium salt, and its form of administration and dosage. Since lithium has been used to treat bipolar disorder, the current study provides an overview of its role in medicine and how this has changed. This review also highlights the importance of this repurposed drug, which appears to have therapeutic cancer potential, and underlines its molecular mechanisms.

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Section: Trends In the Administration Of Lithiummentioning

confidence: 99%

Lithium: A Promising Anticancer Agent

Villegas-Vázquez

Quintas-Granados

Cortés

et al. 2023

Life

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“…Nghiên cứu đã sử dụng PEO N10 có TLPT thấp (100.000 Da) trong lớp dược chất và PEO 303 có TLPT cao (7000.000 Da) trong lớp đẩy. Lựa chọn này là khá tương đồng với nghiên cứu của các tác giả S. Missaghi [6], Z. Zhang [8], C. Wu [9], V. Patel [10]. Thành phần màng bao, trong đó tỷ lệ tá dược hóa dẻo và độ dày màng bao là các thông số quan trọng để kiểm soát tốc độ thấm nước vào viên qua đó ảnh hưởng đến giải phóng thuốc, khi tăng tỷ lệ tá dược hóa dẻo hoặc giảm khối lượng màng bao dẫn đến tốc tăng tốc độ giải phóng thuốc và ngược lại.…”

Section: Bàn Luậnunclassified

“…Đường kính miệng giải phóng ít ảnh hưởng đến Tlag nhưng có ảnh hưởng nhiều đến tốc độ giải phóng thuốc. Kích thước miệng giải phóng càng lớn thì dược chất được giải phóng càng nhanh [10]. Nghiên cứu đã lựa chọn kích thước miệng giải phóng là 0,8 mm, điều này là tương tự với kích thước miệng giải phóng điển hình của dạng bơm thẩm thấu theo C.N.…”

Section: Bàn Luậnunclassified

Preparation of Nifedipine Push-Pull Osmotic Pump Tablets

Trung¹,

Dao²,

Hải³

et al. 2020

MPS

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This study aims to investigate the influence of the formulation factors on the drug release kinetics, thereby selecting the compositions of extended-release nifedipine tablet based on the similarity coefficient f2 obtained when compared with Adalat LA tablet. The formulation factors such as: molecular weight of the polyethylene oxide (PEO) and osmotic agent amount in drug layer and push layer, semi permeable membrane thickness (estimated by coating weight gain), orifice size, type of plasticizers and ratios of coating polymer to plasticizer in semipermeable membrane were evaluated. It was found that developed tablets were able to deliver nifedipine in an approximate zero-order manner up to 20 hours and drug release profile of developed tablets was similar to that from Adalat LA tablets. The developed tablet contained: PEO N10, PEO 303 in drug layer and push layer, respectively; percentages of osmotic agent in drug layer and push layer were 10% and 30%, respectively; weight gain of semipermeable coating was 12%; and orifice size was 0.8 mm. Keywords Nifedipine, GPKD, push-pull osmotic pump, PEO, Tlag. References [1] Vietnamese National Drug Formulary Council, Nifedipine, Vietnamese National Drug Formulary, 2nd edition, Medical Publising House, Hanoi, 2018, pp. 1056-1058 (in Vietnamese).[2] A. Nokhodchi, M.N. Momin, J. Shokri, et al., Factors affecting the release of nifedipine from a swellable elementary osmotic pump, Drug Delivery, 15 (1) (2008) 43-48. https://doi.org/10.1080/10717540701829028[3] R.K. Verma, D.M. Krishna, S. Garg, Formulation aspects in the development of osmotically controlled oral drug delivery systems, Journal of controlled release 79 (1-3) (2002) 7-27. https://doi.org/10.1016/s0168-3659(01)00550-8.[4] The United States Pharmacopeial Convention, Nifedipine Extended-Release Tablets, The United States Pharmacopeia, 41st edition, United Book Press, Baltimore, 2018, pp. 2938 - 2944.[5] V. Malaterre, J. Ogorka, N. Loggia, et al., Approach to design push–pull osmotic pumps, International Journal of Pharmaceutics 376 (1–2) (2009) 56-62. http://dx.doi.org/10.1016/j.ijpharm.2009.04.015.[6] S. Missaghi, P. Patel P, Farrell T. P., et al., Investigation of critical core formulation and process parameters for osmotic pump oral drug delivery, AAPS PharmSciTech 15 (1) (2014) 149-160. http://doi.org/10.1208/s12249-013-0040-4.[7] V. Malaterre, H. Metz, J. Ogorka , et al., Benchtop-magnetic resonance imaging (BT-MRI) characterization of push-pull osmotic controlled release systems, J Control Release 133 (1) (2009) 31-36. http://doi.org/10.1016/j.jconrel.2008.09.007.[8] Z. Zhang, W. Li, S. Nie, et al., Overcome side identification in PPOP by making orifices on both layers, International journal of pharmaceutics 371 (1-2) (2009) 1-7. http://dx.doi.org/10.1016/j.ijpharm.2008.12.006[9] C. Wu, Z. Zhao, Y. Zhao, et al., Preparation of a push–pull osmotic pump of felodipine solubilized by mesoporous silica nanoparticles with a core–shell structure, International Journal of Pharmaceutics,475 (1-2) (2014) 298 - 305 . http://dx.doi.org/10.1016/j.ijpharm.2014.08.033.[10] V. Patel, A. Chudasama, M. Nivsarkar, et al., Push-pull osmotic pump for zero order delivery of lithium carbonate: Development and in vitro characterization, Pharmaceutical development and technology, 17 (3) (2012) 375-382. http://doi.org/10.3109/10837450.2010.542577.[11] C.N. Patra, S. Swain, J. Sruti, et al., Osmotic drug delivery systems: Basics and design approaches, Recent Patents on Drug Delivery & Formulation 7(2) (2013) 1 - 12. http://doi.org/10.2174/1872211311307020007.

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