Purulent Meningitis Caused by Actinomyces Successfully Treated with Rifampicin: A Case Report

Imamura, Keiko; Kamitani, Hideki; Nakayasu, Hiroyuki; Asai, Yukako; Nakashima, Kenichiro

doi:10.2169/internalmedicine.50.4841

Cited by 6 publications

(4 citation statements)

References 12 publications

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“…However, these CSF findings of neutrophil-dominant pleocytosis and moderately decreased glucose are not specific for Nocardia meningitis ( 11 ), with similar findings in meningitis due to Mycobacterium tuberculosis ( 12 ), Actinomyces spp. ( 13 , 14 ), Candida spp. ( 15 , 16 ) and Cryptococcus spp.…”

Section: Discussionmentioning

confidence: 99%

Meningitis and Ventriculitis due to <i>Nocardia araoensis</i> Infection

Yamashita

Kawano²,

Tanigawa³

et al. 2017

Intern. Med.

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A 73-year-old man was admitted to our hospital with disturbance of consciousness, fever and headache. Cerebrospinal fluid (CSF) analysis revealed pleocytosis with neutrophil predominance, increased protein and low glucose. CSF and blood cultures yielded negative results. Antibiotics and antituberculous drugs were started for meningitis. An antimycotic was also added. The patient died from transtentorial hernia 99 days after admission. Autopsy revealed meningitis, ventriculitis and brain abscess, and Nocardia araoensis was detected in pus from the left lateral ventricle. This appears to represent the first report of N. araoensis meningitis complicated by ventriculitis and brain abscess.

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Section: Discussionmentioning

confidence: 99%

Meningitis and Ventriculitis due to <i>Nocardia araoensis</i> Infection

Yamashita

Kawano²,

Tanigawa³

et al. 2017

Intern. Med.

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“…Central nervous system (CNS) infection caused by Actinomyces species is a rare infection, generally presenting as brain abscesses. Reports exist of more uncommon forms of infection, such as meningitis or meningoencephalitis, subdural empyema, or spinal abscess.…”

Section: Introductionmentioning

confidence: 99%

Successful multiple organ donation after donor brain death due to Actinomyces israelii meningitis

Lagunes

Len

Sandiumenge

et al. 2017

Transplant Infectious Dis

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The increasing gap between availability of solid organs for transplantation and the demand has led to the inclusion of donor organs that, according to current guidelines, may be discarded, some of them because of the possibility for transmission of infection to the recipients. We present the first report, to the best of our knowledge, of a case of a brain-dead donor with a localized and treated Actinomyces israelii central nervous system infection who, after a thorough evaluation, provided organs for successful transplant procedures in four recipients. There was no evidence of transmission of infection within a 6-month follow-up. Relative contraindications must be individualized in order to expand the number of real organ donors, emphasizing caution in rare causes for brain death in which patients should be thoroughly evaluated for possible donation.

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“…This clinical syndrome is characterized by its chronic course, the invasion of multiple tissue planes, the formation of sinus tracts and masses resembling malignancy, the production of “sulfur granules,” and its relapsing nature when short courses of antimicrobials are used [ 1 – 3 ]. Although actinomycosis typically involves cervicofacial, thoracic, and abdominal regions, Actinomyces species can cause a variety of infections, including abscesses and skin infections in various locations [ 4 – 6 ], ocular infections [ 5 ], urinary tract infections [ 4 , 6 ], genital infections [ 4 , 6 ], intrauterine contraceptive device infections [ 5 , 7 ], appendicitis [ 4 ], cholecystitis [ 4 ], osteomyelitis [ 5 , 6 ], bacteremia [ 4 – 6 ], endocarditis [ 8 , 9 ], CNS infections [ 10 – 13 ], and many others [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Infections Caused byActinomyces neuii: A Case Series and Review of an Unusual Bacterium

Zelyas

Gee

Nilsson

et al. 2016

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Background. Actinomyces neuii is a Gram-positive bacillus rarely implicated in human infections. However, its occurrence is being increasingly recognized with the use of improved identification systems. Objective. To analyse A. neuii infections in Alberta, Canada, and review the literature regarding this unusual pathogen. Methods. Cases of A. neuii were identified in 2013-2014 in Alberta. Samples were cultured aerobically and anaerobically. A predominant catalase positive Gram-positive coryneform bacillus with no branching was isolated in each case. Testing was initially done with API-CORYNE® (bioMérieux) and isolates were sent to the Provincial Laboratory for Public Health for further testing. Isolates' identities were confirmed by matrix-assisted laser desorption ionization time-of-flight mass spectrometry microbial identification system (MALDI-TOF MS MIS; bioMérieux) and/or DNA sequencing. Results. Six cases of A. neuii infection were identified. All patients had soft tissue infections; typically, incision and drainage were done followed by a course of antibiotics. Agents used included cephalexin, ertapenem, ciprofloxacin, and clindamycin. All had favourable outcomes. Conclusions. While A. neuii is infrequently recognized, it can cause a diverse array of infections. Increased use of MALDI-TOF MS MIS is leading to increased detection; thus, understanding the pathogenicity of this bacterium and its typical susceptibility profile will aid clinical decision-making.

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Purulent Meningitis Caused by Actinomyces Successfully Treated with Rifampicin: A Case Report

Cited by 6 publications

References 12 publications

Meningitis and Ventriculitis due to <i>Nocardia araoensis</i> Infection

Meningitis and Ventriculitis due to <i>Nocardia araoensis</i> Infection

Successful multiple organ donation after donor brain death due to Actinomyces israelii meningitis

Infections Caused byActinomyces neuii: A Case Series and Review of an Unusual Bacterium

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