Purpura of Idiopathic Hyperglobulinemia

Purpura Hyperglobulinemica

“…A modification of this theory to include autoantibody components directed against the capillary wall was also proposed.6 How¬ ever, evidence against an autoimmune mech¬ anism has been presented. 6 Pathological data on tissue specimens has not provided a solution to the problem of pathogenesis.3'5'7,11'18 The principal find¬ ings have consisted of a perivasculitis of small or medium-sized vessels of the upper cutis, with infiltrates composed of both acute and chronic inflammatory cells, wan¬ dering phagocytes, and, in a few cases, plasma cells. Seiden and Wurzel18 specu¬ late that the pathological changes may rep¬ resent a hyperergic response.…”