Purpura fulminans skin loss: surgical management protocols at a regional burns centre

Lowery, Kathryn; Shirley, Rebecca; Shelley, Odhran; Kaniorou-Larai, Magdalini; Philp, Bruce; Dziewulski, Peter

doi:10.1016/j.bjps.2007.01.085

Cited by 15 publications

(8 citation statements)

References 5 publications

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“…It is characterized by widespread activation of the coagulation cascade, resulting in small-vessel thrombosis and the subsequent development of ischemia [2]. This manifests as erythematous macular lesions that develop central necrosis, becoming painful, blue-black and raised due to hemorrhage into the necrotic dermis [5].…”

Section: Discussionmentioning

confidence: 99%

“…There have been many reports of limb amputations as a result of purpura fulminans, but no such report for the involvement of the penis has been made [2–4]. We highlight a case of a 60-year-old male patient who presented with purpura fulminans secondary to idiopathic protein S deficiency, and subsequently underwent a partial glansectomy for necrosis of the penis.…”

Section: Introductionmentioning

confidence: 98%

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Penile necrosis secondary to purpura fulminans: a case report and review of literature

Hogarth

Cheon

Kassam

et al. 2017

Journal of Surgical Case Reports

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We report the case of a 60-year-old Hispanic male with widespread necrotic purpuric lesions involving the penile, suprapubic, inguinal and hip dermis due to purpura fulminans. Purpura fulminans describes a rare syndrome involving intravascular thrombosis and hemorrhagic infarction of the skin; this rapidly progressing syndrome features vascular collapse and disseminated intravascular coagulation. This patient’s penile necrosis involved the majority of the penile shaft and glans penis, and ultimately required partial glansectomy and repeated debridement for treatment. Subsequently, full thickness skin grafting was completed for reconstruction with good effect. While reports of penile necrosis secondary to various causes are documented in the literature, no prior reports describe penile necrosis secondary to purpura fulminans.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Penile necrosis secondary to purpura fulminans: a case report and review of literature

Hogarth

Cheon

Kassam

et al. 2017

Journal of Surgical Case Reports

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“…The skin defects are treated conservatively until they clearly demarcate. Once this occurs and the patient is clinically improved, stable from the sepsis and nutritional point of view and able to withstand surgery, we proceed to excision of the necrotic tissue and allograft the defects with a view to subsequent autografting (Lowery et al 2008).…”

Section: Superficial Partial Thickness Burnsmentioning

confidence: 98%

The use of human deceased donor skin allograft in burn care

2010

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Burns are tissue wounds caused by thermal, electrical, chemical cold or radiation injuries. Deep injuries lead to dermal damage that impairs the ability of the skin to heal and regenerate on its own. Skin autografting following burn excision is considered the current gold standard of care, but lack of patient's own donor skin or unsuitability of the wound for autografting may require the temporary use of dressings or skin substitutes to promote wound healing, reduce pain, and prevent infection and abnormal scarring. These alternatives include deceased donor skin allograft, xenograft, cultured epithelial cells and biosynthetic skin substitutes. Allotransplantation is the transplantation of cells, tissues, or organs, sourced from a genetically non-identical member of the same species as the recipient. Human deceased donor skin allografts represent a suitable and much used temporizing option for skin cover following burn injury. The main advantages for its use include dermoprotection and promotion of reepithelialisation of the wound and their ability to act as skin cover until autografting is possible or re-harvesting of donor sites becomes available. Disadvantages of its use include the limited abundance and availability of donors, possible transmission of disease, the eventual rejection by the host and its handling storing, transporting and associated costs of provision. This paper will explore the role of allograft skin in burn care, defining the indications for its use in burn management and the future potential for allograft tissue banking.

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“…En cas d'impossibilité de mise en place d'une thérapie par pression négative, les allogreffes cutanées ou les xénogref-fes peuvent être une solution alternative. Elles favorisent, par leur qualité de pansement biologique, la création d'un bourgeon propre et propice à la prise de greffes de peau mince ou à la pose de matrices de régénération dermique [23,34,35]. La couverture doit être adaptée à son lit receveur (derme, graisse, péritendon, tendon, articulation, os).…”

Section: Reconstructionunclassified

Prise en charge des lésions des parties molles du purpura fulminans chez l’enfant

Pasquesoone

Belkhou

Gottrand

et al. 2016

Annales de Chirurgie Plastique Esthétique

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Purpura fulminans skin loss: surgical management protocols at a regional burns centre

Cited by 15 publications

References 5 publications

Penile necrosis secondary to purpura fulminans: a case report and review of literature

Penile necrosis secondary to purpura fulminans: a case report and review of literature

The use of human deceased donor skin allograft in burn care

Prise en charge des lésions des parties molles du purpura fulminans chez l’enfant

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