Purple sweet potato anthocyanins attenuate hepatic lipid accumulation through activating adenosine monophosphate–activated protein kinase in human HepG2 cells and obese mice

Hwang, Yong Pil; Choi, Jae Ho; Han, Eun Hee; Kim, Hyung Gyun; Wee, Ji‐Hyang; Jung, Kyung Ok; Jung, Kyung Hee; Kwon, Kwang‐il; Jeong, Tae Cheon; Chung, Young Chul; Jeong, Hye Gwang

doi:10.1016/j.nutres.2011.09.026

Cited by 135 publications

(78 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results corroborate the findings of Basu et al (2010), which demonstrated that the increase of dietary flavonoid content decreases the markers of atherosclerotic lesions in the metabolic syndrome. Furthermore, it has been observed that anthocyanin-rich foods are capable of promoting an improvement in the lipid profile (Basu et al, 2016;Hwang et al, 2011). Analysis of the oxidative status of hepatic tissue showed that there was a decrease in the production of MDA, an important marker of lipid peroxidation and consequently a decrease in the activity of antioxidant defense enzymes (CAT, GST and SOD) in the groups that received LEDE dietary supplementation.…”

Section: Discussionmentioning

confidence: 99%

Euterpe edulis extracts positively modulates the redox status and expression of inflammatory mediators

Freitas

Rômulo

Bianca

et al. 2017

Food and Agricultural Immunology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Euterpe edulis extracts positively modulates the redox status and expression of inflammatory mediators

Freitas

Rômulo

Bianca

et al. 2017

Food and Agricultural Immunology

View full text Add to dashboard Cite

“…Consistent with the present study, anthocyanin supplementation was shown to decrease hepatic lipid accumulation, hepatic insulin resistance and oxidative stress in male mice and rats (Valenti et al 2013). The alleviation of hepatic steatosis is associated with the activations of PPAR-a and AMPK, which induce lipolysis (Hwang et al 2011;Guo et al 2011;Seymour et al 2011). Postmenopausal women and estrogen-deficient female animals easily develop hepatic steatosis with diets in high fat and cholesterol (Kamada et al 2011;Florentino et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Cyanidin and malvidin in aqueous extracts of black carrots fermented with Aspergillus oryzae prevent the impairment of energy, lipid and glucose metabolism in estrogen-deficient rats by AMPK activation

Park

Kang²,

Jeong³

et al. 2015

Genes Nutr

View full text Add to dashboard Cite

Black carrots (Daucus carota L.) are rich in anthocyanins which contribute many health benefits, but are limited by bioavailability and instability when exposed to oxygen, heat and light. Fermenting black carrots may improve the stability, absorption and bioactivity of its anthocyanins. Here, we examined whether and by what mechanisms the long-term consumption of unfermented black carrot extract (BC) and its extracts fermented with Lactobacillus plantarum (BCLP) or Aspergillus oryzae (BCAO) might prevent menopausal symptoms including impaired energy, glucose and lipid metabolism in estrogen-deficient animals with diet-induced obesity. Ovariectomized (OVX) rats were fed four different high-fat diets containing 2 % dextrin (OVX-control), 2 % BC, 2 % BCLP, or 2 % BCAO for 12 weeks. Sham rats were fed high-fat diets containing 2 % dextrin. The contents of total anthocyanins increased in BCAO compared to BC and BCLP, whereas the contents of cyanidin-3-rutinosides, malvidin-3,5-diglycosides and delphine-3-glucoside were lower and cyanidin and malvidin were much higher in BCLP and BCAO than BC. Fat mass and weight gain were lower in descending order of OVX-control [ BC and BCLP [ BCAO due to increased energy expenditure and fat oxidation. However, BC, BCLP and especially BCAO all normalized HOMA-IR, an indicator of insulin resistance and glucose intolerance, in OVX rats. OVX increased serum total and LDL cholesterol and triglycerides, but BC, BCLP and BCAO significantly prevented the increases. BCAO markedly decreased hepatic triglyceride levels by increasing gene expressions of CPT-1 and PPAR-a, which are involved in fatty acid oxidation, and decreasing mRNA expressions of FAS and SREBP-1c, which are associated with fatty acid synthesis. This was related to increased pAMPK ? pACC signaling and improved hepatic insulin signaling (pAkt ? pFOXO-1). Cyanidin and malvidin markedly decreased fat accumulation in 3T3-L1 adipocytes by increasing CPT-1 and decreasing FAS and SREBP-1c expression in comparison with cyanidin-3-rutinoside and malvidin-3,5-diglycosides. In conclusion, with increasing cyanidin and malvidin, BCAO prevented the exacerbation of lipid and glucose metabolism by activating hepatic insulin signaling and AMPK activation by in OVX rats.

show abstract

“…Purified anthocyanins from purple potato, blueberries, and purple corn were reported to reduce the pathogenesis of obesity. 41 The benefits of anthocyanins were attributed to their capacity to activate the adenosine monophosphate-activated protein kinase (AMPK) signaling pathway. Anthocyanins were also reported to down-regulate the levels of sterol regulatory element-binding protein 1 and its target genes including acetyl-coenzyme A carboxylase and fatty acid synthase.…”

Section: Phytochemical Supplementation On Antioxidant Status and Inflmentioning

confidence: 99%

Muscadine Grape (Vitis rotundifolia) and Wine Phytochemicals Prevented Obesity-Associated Metabolic Complications in C57BL/6J Mice

Gourineni

Shay

Chung

et al. 2012

J. Agric. Food Chem.

View full text Add to dashboard Cite

The objective of this study was to determine the effects of muscadine grape or wine (cv. Noble) phytochemicals on obesity and associated metabolic complications. Muscadine grape or wine phytochemicals were extracted using Amberlite FPX66 resin. Male C57BL/6J mice were given a low-fat diet (LF, 10% kcal fat), high-fat diet (HF, 60% kcal fat), HF + 0.4% muscadine grape phytochemicals (HF+MGP), or HF + 0.4% muscadine wine phytochemicals (HF+MWP) for 15 weeks. At 7 weeks, mice fed HF+MGP had significantly decreased body weights by 12% compared to HF controls. Dietary MGP or MWP supplementation reduced plasma content of free fatty acids, triglycerides, and cholesterol in obese mice. Inflammation was alleviated, and activity of glutathione peroxidase was enhanced. Consumption of MGP or MWP improved insulin sensitivity and glucose control in mice. Thus, consumption of muscadine grape and wine phytochemicals in the diet may help to prevent obesity-related metabolic complications.

show abstract

Purple sweet potato anthocyanins attenuate hepatic lipid accumulation through activating adenosine monophosphate–activated protein kinase in human HepG2 cells and obese mice

Cited by 135 publications

References 52 publications

Euterpe edulis extracts positively modulates the redox status and expression of inflammatory mediators

Euterpe edulis extracts positively modulates the redox status and expression of inflammatory mediators

Cyanidin and malvidin in aqueous extracts of black carrots fermented with Aspergillus oryzae prevent the impairment of energy, lipid and glucose metabolism in estrogen-deficient rats by AMPK activation

Muscadine Grape (Vitis rotundifolia) and Wine Phytochemicals Prevented Obesity-Associated Metabolic Complications in C57BL/6J Mice

Contact Info

Product

Resources

About