Purple Rice Bran Extract Attenuates the Aflatoxin B1-Induced Initiation Stage of Hepatocarcinogenesis by Alteration of Xenobiotic Metabolizing Enzymes

Suwannakul, Nattawan; Punvittayagul, Charatda; Jarukamjorn, Kanokwan; Wongpoomchai, Rawiwan

doi:10.7314/apjcp.2015.16.8.3371

Cited by 26 publications

(20 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mechanistic basis of this effect has been found to be varietydependent, reflecting differences in the spectrum of bioactive compounds present in each rice variety (Baek et al, 2015). The high anthocyanin content of purple rice has been associated with an inhibitory effect on the growth of human hepatocellular carcinoma cells (Banjerdpongchai et al, 2013), while extracts of purple rice bran were able to block the first stage of aflatoxin B1-initiated hepatocarcinogenesis by inhibiting key metabolic activating enzymes (Suwannakul et al, 2015). Extracts of red rice have been shown to limit the invasiveness of cancer cells in a dose-dependent manner (Pintha et al, 2014).…”

Section: Anti-cancer Activitymentioning

confidence: 99%

The Genetic Basis and Nutritional Benefits of Pigmented Rice Grain

et al. 2020

View full text Add to dashboard Cite

Improving the nutritional quality of rice grains through modulation of bioactive compounds and micronutrients represents an efficient means of addressing nutritional security in societies which depend heavily on rice as a staple food. White rice makes a major contribution to the calorific intake of Asian and African populations, but its nutritional quality is poor compared to that of pigmented (black, purple, red orange, or brown) variants. The compounds responsible for these color variations are the flavonoids anthocyanin and proanthocyanidin, which are known to have nutritional value. The rapid progress made in the technologies underlying genome sequencing, the analysis of gene expression and the acquisition of global 'omics data, genetics of grain pigmentation has created novel opportunities for applying molecular breeding to improve the nutritional value and productivity of pigmented rice. This review provides an update on the nutritional value and health benefits of pigmented rice grain, taking advantage of both indigenous and modern knowledge, while also describing the current approaches taken to deciphering the genetic basis of pigmentation.

show abstract

Section: Anti-cancer Activitymentioning

confidence: 99%

The Genetic Basis and Nutritional Benefits of Pigmented Rice Grain

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Although white rice is predominantly consumed, pigmented rice is an alternative food known for its health-promoting effects 8. Our group found that purple rice bran extract exhibited antigenotoxic effects on aflatoxin B 1 (AFB 1 )-induced micronucleus formation in rat liver by alteration of several xenobiotic metabolizing enzymes in AFB 1 metabolism 9. A number of varieties of rice and their potential beneficial effects have been investigated 10.…”

Section: Introductionmentioning

confidence: 99%

Antimutagenic and Antioxidant Activities of Thai Rice Brans

et al. 2017

Self Cite

View full text Add to dashboard Cite

BackgroundRice bran is the outer layer of the rice grain, and contains high amounts of bioactive phytochemicals. Here, we investigated and compared chemopreventive properties of purple and white rice bran extracts.MethodsRice bran was extracted with dichloromethane and methanol. Chemical constituents in the extracts were analyzed by colorimetric assay and high performance liquid chromatography. The mutagenicity and antimutagenicity of the extracts were determined via the Salmonella mutation assay. The anticarcinogenic enzyme induction and antioxidant activities of the extracts were examined using Hepa1c1c7 cells and 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay, respectively.ResultsThe methanol extracts of rice bran contained high amounts of phenolic acids, flavonoids, anthocyanins, and phytic acid, whereas large amounts of γ-oryzanol and vitamin E were presented in the dichloromethane extract. None of the extracts were mutagenic to Salmonella typhimurium. All rice bran extracts had strong antimutagenic effects against aflatoxin B1- and 2-amino-3,4-dimethylimidazo [4,5-f]quinoline-induced mutagenesis. The inhibitory effect against 2-aminofluorene-induced mutagenesis was found in the dichloromethane extract, while only the methanol extract of purple rice bran exhibited antimutagenic effects against benzo(a)pyrene. None of the extracts induced quinone reductase activity in Hepa1c1c7 cells. Additionally, the greatest antioxidant capacity was found in the methanol extract of purple rice bran.ConclusionsThe methanol extract of purple rice bran containing high amount of phenolic acids, flavonoids, anthocyanins, and phytic acid showed the most effective antioxidant and antimutagenic activities by inhibiting mutagenic metabolizing enzymes and/or scavenging free radicals. These results demonstrate the nutritional and medical value of Thai rice for cancer prevention.

show abstract

“…The results showed that the extracts could not only inhibit the expression of CYP1A2 and CYP3A, but also increase the expression of GST and UGT which encouraged AFB 1 excretion. Further in in vivo studies, the genotoxicity was evaluated by micronucleus assay, and the result showed lower micronucleus formation in extractpretreated group than AFB 1 treated alone, confirming the capability of purple rice bran extract on the prevention of AFB 1 -induced genotoxicity [39].…”

Section: Purple Ricementioning

confidence: 74%

Modulation of Edible Plants on Hepatocellular Carcinoma Induced by Aflatoxin B₁

Tuntiteerawit¹,

Singto²,

Tadee³

et al. 2020

Phytochemicals in Human Health

View full text Add to dashboard Cite

Aflatoxin B 1 (AFB 1) is one of the major causes of liver cancer especially hepatocellular carcinoma that has high incidence and mortality rate in many countries. Owing to the climate that is suitable for fungal growth, the avoidance of AFB 1 exposure from agricultural product contamination is too difficult. This up-to-date review aims to collect insight on how edible plants attenuate AFB 1toxicity. Cruciferous vegetables, green tea, purple rice, turmeric, green vegetables, ginger, Dialium guineense, Parkia biglobosa, carotenoid-rich fruits and vegetables, Allii Fistulosi Bulbus, and rosemary have reported their capabilities to alleviate AFB 1-toxicity though several mechanisms. All these plants showed anti-genotoxic activity while some of them are able to reduce hepatotoxicity, liver cancer, and oxidative stress and modulate metabolism enzymes induced by AFB 1. Furthermore, a few edible plants could handle AFB 1 in pre-exposure phase including anti-AFB 1 biosynthesis and AFB 1 absorption. Although the detoxification mechanisms of AFB 1 activated by various edible plants have been investigated in pre-clinical study for a decade, clinical trial is still rarely clarified. Further study associating with a protective effect on AFB 1 toxicity still needs to be carried out especially in the clinical study.

show abstract

Purple Rice Bran Extract Attenuates the Aflatoxin B1-Induced Initiation Stage of Hepatocarcinogenesis by Alteration of Xenobiotic Metabolizing Enzymes

Cited by 26 publications

References 28 publications

The Genetic Basis and Nutritional Benefits of Pigmented Rice Grain

The Genetic Basis and Nutritional Benefits of Pigmented Rice Grain

Antimutagenic and Antioxidant Activities of Thai Rice Brans

Modulation of Edible Plants on Hepatocellular Carcinoma Induced by Aflatoxin B₁

Contact Info

Product

Resources

About

Purple Rice Bran Extract Attenuates the Aflatoxin B1-Induced Initiation Stage of Hepatocarcinogenesis by Alteration of Xenobiotic Metabolizing Enzymes

Cited by 26 publications

References 28 publications

The Genetic Basis and Nutritional Benefits of Pigmented Rice Grain

The Genetic Basis and Nutritional Benefits of Pigmented Rice Grain

Antimutagenic and Antioxidant Activities of Thai Rice Brans

Modulation of Edible Plants on Hepatocellular Carcinoma Induced by Aflatoxin B1

Contact Info

Product

Resources

About

Modulation of Edible Plants on Hepatocellular Carcinoma Induced by Aflatoxin B₁