Purple Light-Promoted Coupling of Bromopyridines with Grignard Reagents via SET
Xingyu Lei,
Yihan Wang,
Shanshan Ma
et al.
Abstract:Alkyl- and arylpyridines and 2,2′-bipyridines
are conventionally
prepared by Minisci reactions of pyridines and transition metal-catalyzed
coupling reactions of halopyridines. Herein, purple light-promoted
radical coupling reactions of 2- or 4-bromopyridines with Grignard
reagents in Et2O or a mixture of Et2O and tetrahydrofuran
in regular glassware without the need for a transition metal catalyst
were disclosed for the first time. Methyl, primary and secondary alkyl,
cycloalkyl, aryl, heteroaryl, pyridyl, and… Show more
Selective activation of inert and ubiquitous C(sp³)–H bonds has long been a challenging task in organic synthesis, through which chemists can directly synthesize value-added compounds from inexpensive and readily available...
Selective activation of inert and ubiquitous C(sp³) –H bonds has long been a challenging task in organic synthesis, through which chemists can directly synthesize value-added compounds from inexpensive and readily available...
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