Purple-leaf tea (Camellia sinensis L.) ameliorates high-fat diet induced obesity and metabolic disorder through the modulation of the gut microbiota in mice

Abstract

Background Obesity and its associated diseases have become a major world-wide health problem. Purple-leaf Tea (Camellia sinensis L.) (PLT), that is rich of anthocyanins, has been shown to have preventive effects on obesity and metabolic disorders. The intestinal microbiota has been shown to contribute to inflammation, obesity, and several metabolic disorders. However, whether PLT consumption could prevent obesity and diet-induced metabolic diseases by modulating the gut microbiota, is not clearly understood. Methods In this study, six-week-old male C57BL/6 J mice were fed a normal diet (ND) or a high fat diet (HFD) without or with PLT for 10 weeks. Results PLT modulated the gut microbiota in mice and alleviated the symptoms of HFD-induced metabolic disorders, such as insulin resistance, adipocyte hypertrophy, and hepatic steatosis. PLT increased the diversity of the microbiota and the ratio of Firmicutes to Bacteroidetes. f_Barnesiellaceae, g_Barnesiella, f_Ruminococcaceae, and f_Lachnospiraceae were discriminating faecal bacterial communities of the PLT mice that differed from the HFD mice. Conclusions These data indicate that PLT altered the microbial contents of the gut and prevented microbial dysbiosis in the host, and consequently is involved in the modulation of susceptibility to insulin resistance, hepatic diseases, and obesity that are linked to an HFD.

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“…rich in anthocyanins prevented the effects of obesity and metabolic disorders and prevented microbial dysbiosis in C57BL/6J mice HFD‐fed with purple tea for 10 weeks. Purple tea increased the diversity of the microbiota and attenuated the rise of the F / B ratio caused by the HFD; moreover, the families Barnesiellaceae , Ruminococcaceae , and Lachnospiraceae , together with the genus Barnesiella , increased compared to HFD alone 83 . The administration of Angelica keiskei juice to HFD‐fed C57BL/6 mice prevented weight gain, decreased fat accumulation, blood glucose, serum lipid levels, and normalized gut dysbiosis.…”

“…Purple tea increased the diversity of the microbiota and attenuated the rise of the F / B ratio caused by the HFD; moreover, the families Barnesiellaceae , Ruminococcaceae , and Lachnospiraceae , together with the genus Barnesiella , increased compared to HFD alone. 83 The administration of Angelica keiskei juice to HFD‐fed C57BL/6 mice prevented weight gain, decreased fat accumulation, blood glucose, serum lipid levels, and normalized gut dysbiosis. Angelica keiskei had various flavonoids, among which coumarins, phenolic acids, chalcones, and terpenoids; chalcones (xanthoangelol and 4‐hydroxyderricin) are considered the major components.…”