Purple Grape Juice Improves Endothelial Function and Reduces the Susceptibility of LDL Cholesterol to Oxidation in Patients With Coronary Artery Disease

Stein, James H.; Keevil, Jon G.; Wiebe, Donald A.; Aeschlimann, Susan E.; Folts, John D.

doi:10.1161/01.cir.100.10.1050

Cited by 512 publications

(301 citation statements)

References 55 publications

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“…The urinary yield of anthocyanins was reported as 0.036± 0.043% of the ingested dose after consumption of a blackcurrant juice similar to that consumed in this study (Hollands et al, 2008). Vasodilatory effects of cyanidin-3-glucoside, and delphinidin glycoside-rich and cyanidin glycoside-rich juices have been reported but only at higher levels of intake (Stein et al, 1999;Fitzpatrick et al, 2000;Xu et al, 2004;George et al, 2009).…”

Section: Discussionsupporting

confidence: 67%

A randomised trial to investigate the effects of acute consumption of a blackcurrant juice drink on markers of vascular reactivity and bioavailability of anthocyanins in human subjects

et al. 2011

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Background/Objectives: To study the bioavailability of anthocyanins and the effects of a 20% blackcurrant juice drink on vascular reactivity, plasma antioxidant status and other cardiovascular disease risk markers. Subjects/Methods: The study was a randomised, cross-over, double-blind, placebo-controlled acute meal study. Twenty healthy volunteers (11 females and 9 males) were recruited, and all subjects completed the study. Fasted volunteers consumed a 20% blackcurrant juice drink (250 ml) or a control drink following a low-flavonoid diet for the previous 72 h. Vascular reactivity was assessed at baseline and 120 min after juice consumption by laser Doppler imaging (LDI). Plasma and urine samples were collected periodically over an 8-h period for analysis, with a final urine sample collected at 24 h. The cross-over was performed after a 4-week washout. Results: There were no significant effects of the 20% blackcurrant juice drink on acute measures of vascular reactivity, biomarkers of endothelial function or lipid risk factors. Consumption of the test juice caused increases in plasma vitamin C (P ¼ 0.006), and urinary anthocyanins (Po0.001). Delphinidin-3-rutinoside and cyanidin-3-rutinoside were the main anthocyanins excreted in urine with delphinidin-3-glucoside also detected. The yield of anthocyanins in urine was 0.021±0.003% of the dietary intake of delphinidin glycosides and 0.009±0.002% of the dietary intake of cyanidin glycosides. Conclusions: The juice consumption did not have a significant effect on vascular reactivity. Anthocyanins were present at low concentrations in the urine, and microbial metabolites of flavonoids were detected in plasma after juice consumption.

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Section: Discussionsupporting

confidence: 67%

A randomised trial to investigate the effects of acute consumption of a blackcurrant juice drink on markers of vascular reactivity and bioavailability of anthocyanins in human subjects

et al. 2011

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“…This hypothesis is supported by mechanistic findings related to polyphenols and other compounds contained in wine, and especially in red wine, that may exert inhibition of platelet aggregation, 13 antioxidizing properties, and vasorelaxing and other beneficial effects on endothelial function. [14][15][16] Genetic studies support these mechanisms. 17 In spite of laboratory findings, most epidemiologic studies have failed to detect large differences in benefits between the various types of alcoholic beverages.…”

Section: Introductionmentioning

confidence: 99%

Type of alcoholic beverage and first acute myocardial infarction: A case‐control study in a mediterranean country

Fernández-Jarne

Martínez-Losa

Serrano-Martínez

et al. 2003

Clinical Cardiology

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SummaryBackground: Although international comparisons have consistently found an inverse association between wine and coronary heart disease, few epidemiologic studies are available in Southern Europe. We assessed the association of wine, red wine, and the pattern of drinking wine during meals with the risk of myocardial infarction.Hypothesis: We specifically evaluated three hypotheses: (1) Is the protection against incidence of nonfatal myocardial infarction stronger for wine than for other alcoholic beverages? (2) Does the wine consumed during meals represent a more beneficial pattern of alcohol consumption? (3) Is red wine more advantageous than other types of wine?Methods: A case-control study (171 cases, 171 matched controls) was conducted in Spain. Multiple dietary and nondietary potential confounders were assessed.Results: Exposure to wine, red wine, and wine during meals was associated with risk reductions similar to those of other alcoholic beverages (point estimates of the odds ratio for low and high intake were 0.48 and 0.38 for wine; 0.42 and 0.55 for other beverages). However, after controlling for total alcohol intake, wine consumption (g/day) improved the prediction of a myocardial infarction.Conclusions: Our data showed that red wine or drinking wine during meals was similar to alcohol from other sources

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“…Other researchers using subjects at greater CV risk have found improvements in brachial artery flow mediated dilatation (FMD) measurements following isoflavone supplementation for 12 weeks in patients with prior ischaemic stroke (24) and similar findings have been reported with black tea (25) and purple grape juice (26) in subjects with angiographically proven coronary artery disease, though the latter was not a randomized trial.…”

Section: Discussionmentioning

confidence: 61%

Effects of a beverage rich in (poly)phenols on established and novel risk markers for vascular disease in medically uncomplicated overweight or obese subjects: A four week randomized placebo-controlled trial

et al. 2016

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Objective: To determine if (poly)phenols alter cardiovascular risk factors, we assessed the potential of a high (poly)phenol beverage drink, rich in hydroxycinnamates and flavonoids, to modify vascular function in middle aged, overweight or obese subjects without medical comorbidity in a randomized placebo controlled pilot study. Methods: Randomly assigned active 250ml beverages containing 361mg of (poly)phenols and 120mg of vitamin C or placebo (no polyphenol / vitamin C) were taken twice daily for 4 weeks. Both beverages contained 40 kcals/250 ml. The primary end-points were pulse wave velocity (PWV) and cutaneous microvascular responses to sodium nitroprusside (SNP) and acetyl choline (ACh) laser doppler iontophoresis. A range of established and novel plasma markers were also measured. Results:Twenty subjects received active beverage and 19 placebo; all completed the study. There was no difference in cutaneous vascular response to either SNP or ACh with mean group differences (log∆ area under perfusion curve) of 0.30 (-0.65, 1.26) and 0.35 (-0.11, 0.81) respectively. Nor was there evidence of a change in log PWV with a mean group difference of 0.029m/s (-0.042, 0.10). No significant differences were seen in plasma leptin, apolipoproteins, cystatin C, insulin, adiponectin, CRP, ICAM-1, E-Selectin or t-PA, but IL-6 increased in active versus placebo recipients (0.32 vs -0.18 pg/ml; p=0.010). Conculsion: There was no evidence for a short-term beneficial effect of (poly)phenol intervention on microcutaneous vascular response or pulse wave velocity, and no evidence for a benefit on established or novel risk factors in overweight or obese subjects. Our results do not support a short-term benefit of (poly)phenol supplementation on cardiometabolic risk. PWV pulse wave velocity; SNP sodium nitroprusside; ACh acetyl choline, HPLC-MS 2 high performance liquid chromatography-tandem mass spectrometry

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Purple Grape Juice Improves Endothelial Function and Reduces the Susceptibility of LDL Cholesterol to Oxidation in Patients With Coronary Artery Disease

Cited by 512 publications

References 55 publications

A randomised trial to investigate the effects of acute consumption of a blackcurrant juice drink on markers of vascular reactivity and bioavailability of anthocyanins in human subjects

A randomised trial to investigate the effects of acute consumption of a blackcurrant juice drink on markers of vascular reactivity and bioavailability of anthocyanins in human subjects

Type of alcoholic beverage and first acute myocardial infarction: A case‐control study in a mediterranean country

Effects of a beverage rich in (poly)phenols on established and novel risk markers for vascular disease in medically uncomplicated overweight or obese subjects: A four week randomized placebo-controlled trial

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