2023
DOI: 10.1080/19768354.2023.2203211
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Puromycin-induced kidney injury and subsequent regeneration in adult zebrafish

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“…Toxic drugs as well as genetic modification in rodents have been extensively used to define mechanisms of disease progression [1]. Toxins such as adriamycin and puromycin induce proteinuric nephropathy such as podocyte injury of nephrotic syndrome [2][3][4][5]. The anthracyclines, including daunorubicin and its 14-hydroxy derivative doxorubicin (adriamycin), are widely used agents in the treatment of cancer, but the cardiotoxicity and nephrotoxicity limit its potential for use.…”
Section: Introductionmentioning
confidence: 99%
“…Toxic drugs as well as genetic modification in rodents have been extensively used to define mechanisms of disease progression [1]. Toxins such as adriamycin and puromycin induce proteinuric nephropathy such as podocyte injury of nephrotic syndrome [2][3][4][5]. The anthracyclines, including daunorubicin and its 14-hydroxy derivative doxorubicin (adriamycin), are widely used agents in the treatment of cancer, but the cardiotoxicity and nephrotoxicity limit its potential for use.…”
Section: Introductionmentioning
confidence: 99%