2010
DOI: 10.1523/jneurosci.4344-10.2010
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Purkinje Cell NMDA Receptors Assume a Key Role in Synaptic Gain Control in the Mature Cerebellum

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Cited by 91 publications
(122 citation statements)
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References 32 publications
(41 reference statements)
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“…1) leads to the question of whether CF activity indeed promotes LTD by amplifying calcium transients, or whether it contributes other signaling factors that trigger the switch toward LTD. For example, CF activity results in the release of corticotropin-releasing factor, which promotes LTD at PF and CF synapses by activation of PKC (33,34). In addition, in the mature cerebellum, CF stimulation recruits a specific calcium source that is not available at PF synapses, postsynaptically located NMDA receptors (7,35,36). It is conceivable that these CF-specific signaling components contribute to LTD.…”
Section: Discussionmentioning
confidence: 99%
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“…1) leads to the question of whether CF activity indeed promotes LTD by amplifying calcium transients, or whether it contributes other signaling factors that trigger the switch toward LTD. For example, CF activity results in the release of corticotropin-releasing factor, which promotes LTD at PF and CF synapses by activation of PKC (33,34). In addition, in the mature cerebellum, CF stimulation recruits a specific calcium source that is not available at PF synapses, postsynaptically located NMDA receptors (7,35,36). It is conceivable that these CF-specific signaling components contribute to LTD.…”
Section: Discussionmentioning
confidence: 99%
“…This activation pattern is applied at 1 Hz for 5 min. With this protocol, too, omission of CF activation causes LTP instead (7). All stimulus protocols cause postsynaptically expressed forms of LTD/LTP (6,7).…”
Section: Significancementioning
confidence: 92%
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