Purines 2008 Meeting 29 June – 2 July 2008, Copenhagen, Denmark
Abstract:Chemosensory transduction, allows the brain to sense and regulate the levels of blood gasses such as CO2 and important metabolites such as glucose. At least one class of CO2 chemosensory cell at the ventral surface of the medulla releases ATP as a key step in the detection of CO2. We have studied the mechanisms of CO2-dependent ATP release at the ventral medullary surface and have discovered a new principle of CO2 chemosensory transduction. ATP is released via the gating of connexin 26 (Cx26) hemichannels to m… Show more
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