Purinergic signalling in the kidney in health and disease

Burnstock, Geoffrey; Evans, Louise; Bailey, Matthew A.

doi:10.1007/s11302-013-9400-5

Cited by 82 publications

(76 citation statements)

References 415 publications

(311 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study suggests that the adenosine signaling pathway may regulate the physiology of all Xenopus adult organs, in a similar way to mammals [3,5,[62][63][64]. In particular, the kidney, intestine, and brain appear to be major sites of expression in the adult for the pathway members, including the enzymes involved in generating or hydrolyzing adenosine, adora receptors and nucleotide receptors.…”

Section: Specific Functions For the Different Members In Xenopusmentioning

confidence: 59%

Comparative genomic and expression analysis of the adenosine signaling pathway members in Xenopus

Tocco

Pinson²,

Thiébaud

et al. 2014

Purinergic Signalling

View full text Add to dashboard Cite

Adenosine is an endogenous molecule that regulates many physiological processes via the activation of four specific G-protein-coupled ADORA receptors. Extracellular adenosine may originate either from the hydrolysis of released ATP by the ectonucleotidases or from cellular exit via the equilibrative nucleoside transporters (SLC29A). Adenosine extracellular concentration is also regulated by its successive hydrolysis into uric acid by membrane-bound enzymes or by cell influx via the concentrative nucleoside transporters (SLC28A). All of these members constitute the adenosine signaling pathway and regulate adenosine functions. Although the roles of this pathway are quite well understood in adults, little is known regarding its functions during vertebrate embryogenesis. We have used Xenopus laevis as a model system to provide a comparative expression map of the different members of this pathway during vertebrate development. We report the characterization of the different enzymes, receptors, and nucleoside transporters in both X. laevis and X. tropicalis, and we demonstrate by phylogenetic analyses the high level of conservation of these members between amphibians and mammals. A thorough expression analysis of these members during development and in the adult frog reveals that each member displays distinct specific expression patterns. These data suggest potentially different developmental roles for these proteins and therefore for extracellular adenosine. In addition, we show that adenosine levels during amphibian embryogenesis are very low, confirming that they must be tightly controlled for normal development.

show abstract

Section: Specific Functions For the Different Members In Xenopusmentioning

confidence: 59%

Comparative genomic and expression analysis of the adenosine signaling pathway members in Xenopus

Tocco

Pinson²,

Thiébaud

et al. 2014

Purinergic Signalling

View full text Add to dashboard Cite

show abstract

“…In many cells, these receptors are coupled, via several G proteins, to phospholipase C that produces InsP 3 and initiates Ca 2þ release from the endoplasmic reticulum. The ATP-induced Ca 2þ signalling mediated through the metabotropic route seems to be almost universal in non-excitable cells, being present in immune cells [236], in neuroglia [237], in kidney [238], in cells of urinary tract [239], in skin, bone and cartilages [240], in endocrine glands [241], etc. The P2Y receptors and their downstream Ca 2þ signalling can be activated not only by ATP, but also by other nucleotides including ADP, UTP, UDP and UDP-glucose [242,243].…”

Section: Ca 2þ As a Regulator Of Programmed Cell Deathmentioning

confidence: 99%

Inseparable tandem: evolution chooses ATP and Ca²⁺to control life, death and cellular signalling

Plattner

Verkhratsky

2016

Phil. Trans. R. Soc. B

View full text Add to dashboard Cite

From the very dawn of biological evolution, ATP was selected as a multipurpose energy-storing molecule. Metabolism of ATP required intracellular free Ca 2þ to be set at exceedingly low concentrations, which in turn provided the background for the role of Ca 2þ as a universal signalling molecule. The early-eukaryote life forms also evolved functional compartmentalization and vesicle trafficking, which used Ca 2þ as a universal signalling ion; similarly, Ca 2þ is needed for regulation of ciliary and flagellar beat, amoeboid movement, intracellular transport, as well as of numerous metabolic processes. Thus, during evolution, exploitation of atmospheric oxygen and increasingly efficient ATP production via oxidative phosphorylation by bacterial endosymbionts were a first step for the emergence of complex eukaryotic cells. Simultaneously, Ca 2þ started to be exploited for shortrange signalling, despite restrictions by the preset phosphate-based energy metabolism, when both phosphates and Ca 2þ interfere with each other because of the low solubility of calcium phosphates. The need to keep cytosolic Ca 2þ low forced cells to restrict Ca 2þ signals in space and time and to develop energetically favourable Ca 2þ signalling and Ca 2þ microdomains. These steps in tandem dominated further evolution. The ATP molecule (often released by Ca 2þ -regulated exocytosis) rapidly grew to be the universal chemical messenger for intercellular communication; ATP effects are mediated by an extended family of purinoceptors often linked to Ca 2þ signalling. Similar to atmospheric oxygen, Ca 2þ must have been reverted from a deleterious agent to a most useful (intra-and extracellular) signalling molecule. Invention of intracellular trafficking further increased the role for Ca 2þ homeostasis that became critical for regulation of cell survival and cell death. Several mutually interdependent effects of Ca 2þ and ATP have been exploited in evolution, thus turning an originally unholy alliance into a fascinating success story.This article is part of the themed issue 'Evolution brings Ca 2þ and ATP together to control life and death'.

show abstract

“…Purinoceptors are present in all peripheral tissues, being involved in short-term as well as long-term regulation of different functions, including neuromuscular and synaptic transmission and secretion in gut [35], and secretion in kidneys [36], liver [37] and reproductive systems [38]. In vascular [16] and respiratory systems, ATP mediates reflex activities via activation of sensory nerves [39].…”

Section: Introductionmentioning

confidence: 99%

Short- and long-term (trophic) purinergic signalling

Burnstock¹

2016

Phil. Trans. R. Soc. B

Self Cite

View full text Add to dashboard Cite

There is long-term (trophic) purinergic signalling involving cell proliferation, differentiation, motility and death in the development and regeneration of most systems of the body, in addition to fast purinergic signalling in neurotransmission, neuromodulation and secretion. It is not always easy to distinguish between short-and long-term signalling. For example, adenosine triphosphate (ATP) can sometimes act as a short-term trigger for long-term trophic events that become evident days or even weeks after the original challenge. Examples of short-term purinergic signalling during sympathetic, parasympathetic and enteric neuromuscular transmission and in synaptic transmission in ganglia and in the central nervous system are described, as well as in neuromodulation and secretion. Long-term trophic signalling is described in the immune/defence system, stratified epithelia in visceral organs and skin, embryological development, bone formation and resorption and in cancer. It is likely that the increase in intracellular Ca 2þ in response to both P2X and P2Y purinoceptor activation participates in many short-and long-term physiological effects. This article is part of the themed issue 'Evolution brings Ca 2þ and ATP together to control life and death'.

show abstract

Purinergic signalling in the kidney in health and disease

Cited by 82 publications

References 415 publications

Comparative genomic and expression analysis of the adenosine signaling pathway members in Xenopus

Comparative genomic and expression analysis of the adenosine signaling pathway members in Xenopus

Inseparable tandem: evolution chooses ATP and Ca²⁺to control life, death and cellular signalling

Short- and long-term (trophic) purinergic signalling

Contact Info

Product

Resources

About

Purinergic signalling in the kidney in health and disease

Cited by 82 publications

References 415 publications

Comparative genomic and expression analysis of the adenosine signaling pathway members in Xenopus

Comparative genomic and expression analysis of the adenosine signaling pathway members in Xenopus

Inseparable tandem: evolution chooses ATP and Ca2+to control life, death and cellular signalling

Short- and long-term (trophic) purinergic signalling

Contact Info

Product

Resources

About

Inseparable tandem: evolution chooses ATP and Ca²⁺to control life, death and cellular signalling