Purinergic signaling: decoding its role in COVID-19 pathogenesis and promising treatment strategies

Shafaghat, Zahra; Ghomi, Amir-Hossein Khosrozadeh; Khorramdelazad, Hossein; Safari, Elaheh

doi:10.1007/s10787-023-01344-4

Cited by 1 publication

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“…In general, we can conclude that during CVHC the number of NK cells with the expression of ecto-5’-nucleotidase increased. Moreover, the inhibitory effect of purinergic regulation on NK cells was also proven using the example of viral infections [ 41 ], and also in patients with severe fibrosis, the level of CD38 + CD73 + NK cells increased.…”

Section: Discussionmentioning

confidence: 99%

Association of Blood NK Cell Phenotype with the Severity of Liver Fibrosis in Patients with Chronic Viral Hepatitis C with Genotype 1 or 3

Tsukanov,

Savchenko,

Cherepnin

et al. 2024

Diagnostics

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Background: NK cells phenotype and functional state in different genotypes of chronic viral hepatitis C (CVHC), depending on liver fibrosis severity, have not been sufficiently studied, which limits the possibilities for the development of pathology therapy. Methods: The CVHC diagnosis was based on the EASL recommendations (2018). Clinical examination with liver elastometry was performed in 297 patients with genotype 1 and in 231 patients with genotype 3 CVHC. The blood NK cells phenotype was determined by flow cytometry in 74 individuals with genotype 1 and in 69 individuals with genotype 3 CVHC. Results: The frequency of METAVIR liver fibrosis stages F3–F4 was 32.5% in individuals with genotype 3, and 20.5% in individuals with genotype 1 CVHC (p = 0.003). In patients with both genotype 1 and genotype 3 CVHC, a decrease in the total number of blood NK cells, CD56brightCD16+ NK cells and an increase in the proportion of CD56dimCD16+ NK cells, CD94+ and CD38 + CD73+ NK cells were registered in patients with fibrosis stage F3–F4 by METAVIR in comparison with persons with METAVIR fibrosis stage F0–F1. Conclusions: In patients with both genotype 1 and genotype 3 CVHC, an imbalance in the ratio between cytokine-producing and cytotoxic NK cells and an increase in the content of NK cells that express inhibitory molecules were determined in patients with severe liver fibrosis.

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Section: Discussionmentioning

confidence: 99%