Abstract:Fibroblast Growth Factor‐21 (FGF‐21) is a myokine which induce fiber type transformation and metabolic adaptations in muscle. However, little is known about the molecular mechanisms involved in the regulation of FGF‐21 expression in skeletal muscle in non‐pathological conditions. We have previously described that purinergic signaling is related with muscle adaptations and IL6‐myokine production through the “excitation‐transcription coupling” (ETC) mechanism, in which extracellular ATP (eATP) promotes gene expr… Show more
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