Purinergic regulation of epithelial transport

Intestinal Anion Exchanger Down-regulated in Adenoma (DRA) Is Inhibited by Intracellular Calcium

“…Therefore, we tested UTP because it acts via stimulation of P2Y receptors and is independent of protein kinase C (29). Furthermore, postconfluent Caco-2 cells express P2Y receptors that can be stimulated by UTP resulting in an increase of intracellular calcium (30).…”

Cardiomyogenesis of embryonic stem cells upon purinergic receptor activation by ADP and ATP

“…Purinoceptor signal transduction is mediated through various numbers of signaling mediators to exert unique roles in cells [29,30]. Metabotropic P2Y receptors are mostly coupled to Gq/11 proteins activating phospholipase C-β (PLC-β) and the phosphoinositide cascade, with subsequent IP3 formation and [Ca 2+ ] i release from intracellular stores.…”

Mechanical Forces Impair Alveolar Ion Transport Processes – A Putative Mechanism Contributing to the Formation of Pulmonary Edema

“…In addition, different signaling mediators and ATP in particular are released in response to mechanical stress (Homolya et al, 2000;Okada et al, 2006;Button et al, 2007). The release of ATP offers the possibility to initiate a variety of different cellular reactions by acting on multiple purinergic receptors -including P2X, P2Y and P1 receptors (Leipziger, 2003;Bucheimer and Linden, 2004;Barth and Kasper, 2009). The relevance of purinergic signaling has been implicated by a study identifying alterations of transepithelial ion transport processes in airway epithelia in response to adenosine as a factor contributing to cystic fibrosis lung disease (Tarran et al, 2005;Tarran et al, 2006).…”