Purinergic dysfunction in bipolar disorder: Any role for the antioxidant uric acid as a trait and state biomarker?

Bartoli, Francesco; Carrà, Giuseppe; Clerici, Massimo

doi:10.1111/pcn.12518

Cited by 8 publications

(6 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the prevention of OS can delay the occurrence of such CNS diseases and improve their prognostic outcomes. URIC is a potent endogenous antioxidant that functions in resisting OS-mediated neuronal death and neurodegeneration, as suggested by in vivo and in vitro studies (Chen et al, 2013;Bartoli et al, 2017). As a result, the present work indicates that URIC exerts antioxidant and neuroprotective effects in MS.…”

Section: Discussionsupporting

confidence: 65%

Association of Serum Uric Acid Levels in Meige’s Syndrome

et al. 2021

View full text Add to dashboard Cite

Uric acid (URIC) is a natural antioxidant, and it has been shown that low levels of URIC could be a risk factor for the development of Parkinson’s disease. Our aim was to investigate whether URIC also plays a role in Meige’s syndrome (MS). We conducted a cohort study to compare serum URIC levels between patients with MS and healthy controls. In addition, we analyzed the impact of URIC on the risk of MS and symptom severity. Compared with normal subjects, URIC content was remarkably decreased in MS patients. In addition, URIC was regarded as a protective factor for MS, as verified by multivariate logistic regression models. We also found non-linear relationships between the levels of serum URIC and the incidence rate of MS and the Burke-Fahn-Marsden dystonia rating scale score. Our study is the first to show a connection between serum URIC levels and MS. Low serum URIC levels indicate an increased risk of MS incidence and more severe clinical symptoms. Our findings provide new insights into the prevention and treatment of MS.

show abstract

Section: Discussionsupporting

confidence: 65%

Association of Serum Uric Acid Levels in Meige’s Syndrome

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In the past few years, a number of studies have investigated the changes of UA in patients suffering BPDs; however, the data are inconsistent and even controversial (20, 22, 35, 36). This may be due to various confounders involved in studies because the nature of BPD is a complex, chronic, and heterogeneous psychiatric disease (37).…”

Section: Discussionmentioning

confidence: 99%

Patients With Drug-Naive Bipolar Disorder in Remission After 8 Weeks of Treatment Had Decreased Serum Uric Acid Concentrations

et al. 2019

View full text Add to dashboard Cite

Background: Evidence indicates that the serum concentration of uric acid (UA) in patients may relate both to the pathophysiology and therapeutics of bipolar disorder (BPD). The purpose of this study was to examine the changes and clinical significance of serum UA concentrations in first-episode manic patients suffering from BPD.Methods: Seventy-six drug-naive patients with first-episode bipolar mania and 76 age- and gender-matched healthy subjects were recruited. Young Mania Rating Scale and Hamilton Depression Rating Scale were used to assess clinical symptoms. We tested serum UA concentrations by sandwich enzyme-linked immunosorbent assay at baseline and at the end of 8-week treatment in BPD patients and in the control group.Results: After 8-week quetiapine and sodium valproate treatment, this study revealed that the serum UA concentrations in remitted patients were significantly lower than nonremitted patients; however, those remitted patients still had higher serum UA than healthy controls. We discovered that the baseline UA concentration was higher in nonremitted than remitted patients after 8 weeks of treatment. Finally, a positive association was found between serum UA and symptom relief in the first episode of manic disorder patients.Conclusion: Patients with first-episode BPD had high levels of serum UA, which responds to treatment mainly in remitted patients. Our results suggest that serum UA concentrations might present potentially a trait marker in bipolar patients.

show abstract

“…Elevated UA levels have been associated with specific manic traits such as impulsivity, irritability, increased drive, disinhibition, and hyperthymia (Machado-Vieira et al 2002;Lorenzi et al 2010;Sutin et al 2014). Manic patients demonstrate increased serum UA compared to those with bipolar depression or MDD (Bartoli et al 2017b). Higher serum UA is also predictive of bipolar conversion in currently depressed patients (Oliveira et al 2019).…”

Section: Purinergic System and Maniamentioning

confidence: 99%

Intracellular Signaling Cascades in Bipolar Disorder

Jones

Rong

Shariq

et al. 2020

Bipolar Disorder: From Neuroscience to Treatment

View full text Add to dashboard Cite

Bipolar spectrum disorders carry a significant public health burden. Disproportionately high rates of suicide, incarceration, and comorbid medical conditions necessitate an extraordinary focus on understanding the intricacies of this disease. Elucidating granular, intracellular details seems to be a necessary preamble to advancing promising therapeutic opportunities. In this chapter, we review a wide range of intracellular mechanisms including mitochondrial energetics, calcium

show abstract

Purinergic dysfunction in bipolar disorder: Any role for the antioxidant uric acid as a trait and state biomarker?

Cited by 8 publications

References 8 publications

Association of Serum Uric Acid Levels in Meige’s Syndrome

Association of Serum Uric Acid Levels in Meige’s Syndrome

Patients With Drug-Naive Bipolar Disorder in Remission After 8 Weeks of Treatment Had Decreased Serum Uric Acid Concentrations

Intracellular Signaling Cascades in Bipolar Disorder

Contact Info

Product

Resources

About