Purinergic cation channels in neurons of rabbit vesical parasympathetic ganglia

Nishimura, Toshihiko; Tokimasa, Takayuki

doi:10.1016/0304-3940(96)12805-6

Cited by 18 publications

(6 citation statements)

References 12 publications

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“…For instance, chick ciliary parasympathetic ganglion neurones are stimulated by nucleotides in a mechanism that involves the opening of nonselective cation channels [Abe et al, 1995]. Also, rabbit neurones from the vesical parasympathetic ganglia present P2X receptors that induced inward currents after ATP stimulation, which may produce the release of ACh to the synaptic cleft [Nishimura and Tokimasa, 1996]. Moreover, an ATP ligand ion channel has been described on a cholinergic presynaptic terminal.…”

Section: Discussionmentioning

confidence: 98%

Therapeutic potential of nucleotides in the eye

Pintor

Peral

2001

Drug Development Research

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Adenine mononucleotides present the ability to produce changes in the intraocular pressure in New Zealand rabbits. Two main groups of compounds were found in terms of their behaviour-on the one hand, those that increased intraocular pressure, and on the other hand, those that reduced it. The hypotensive compounds showed a concentration-response behaviour, and were blocked by the P2 receptor antagonist pyridoxalphosphate-6-azophenyl-2′,4′-disulfonic acid. Moreover, the hypotensive compounds were unaffected by the pretreatment with sympathetic antagonists but were completely abolished by the parasympathetic antagonists. This fact suggests the possibility of these P2 receptors to be present at the cholinergic terminal that control intraocular pressure. Adenine mononucleotides also were assayed in their ability to increase tear secretion rate. This study showed that tear secretion is stimulated via P2Y 2 receptors. Drug Dev. Res. 52:190-195, 2001.

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Section: Discussionmentioning

confidence: 98%

Therapeutic potential of nucleotides in the eye

Pintor

Peral

2001

Drug Development Research

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“…Single electrode voltage-clamp techniques in rabbit vesical parasympathetic ganglion cells [528] showed that ATP and ADP, but not AMP or adenosine, caused an inward current associated with increased conductance. Suramin and Reactive blue 2, but not hexamethonium reversibly depressed the actions of ATP and ADP, suggesting that ATP activates cation channels through P2X receptors in rabbit parasympathetic neurones.…”

Section: Intramural Bladder Neurones and Pelvic Gangliamentioning

confidence: 98%

Purinergic signalling in the urinary tract in health and disease

Burnstock

2013

Purinergic Signalling

140

149

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Purinergic signalling is involved in a number of physiological and pathophysiological activities in the lower urinary tract. In the bladder of laboratory animals there is parasympathetic excitatory cotransmission with the purinergic and cholinergic components being approximately equal, acting via P2X1 and muscarinic receptors, respectively. Purinergic mechanosensory transduction occurs where ATP, released from urothelial cells during distension of bladder and ureter, acts on P2X3 and P2X2/3 receptors on suburothelial sensory nerves to initiate the voiding reflex, via low threshold fibres, and nociception, via high threshold fibres. In human bladder t h e p u r i n e rg i c c o m p o n e n t o f p a r a s y m p a t h e t i c cotransmission is less than 3 %, but in pathological conditions, such as interstitial cystitis, obstructed and neuropathic bladder, the purinergic component is increased to 40 %. Other pathological conditions of the bladder have been shown to involve purinoceptor-mediated activities, including multiple sclerosis, ischaemia, diabetes, cancer and bacterial infections. In the ureter, P2X7 receptors have been implicated in inflammation and fibrosis. Purinergic therapeutic strategies are being explored that hopefully will be developed and bring benefit and relief to many patients with urinary tract disorders.

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“…Patch clamp recordings in dissociated neurons from the rat and rabbit pelvic ganglia (475), and guinea pig bladder ganglia (737) revealed that ATP evokes a rapid depolarization or inward current via P2X receptors. Although 2-MeSATP and ATP are approximately equipotent in rat neurons α,β-me-ATP evokes only small responses consistent with the immunohistochemical data indicating that high levels of P2X2 receptors but not P2X1 or P2X3 receptors are expressed in these ganglia (737).…”

Section: Modulation Of Transmission In Autonomic Gangliamentioning

confidence: 99%

Neural Control of the Lower Urinary Tract

1997

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This article summarizes anatomical, neurophysiological, pharmacological, and brain imaging studies in humans and animals that have provided insights into the neural circuitry and neurotransmitter mechanisms controlling the lower urinary tract. The functions of the lower urinary tract to store and periodically eliminate urine are regulated by a complex neural control system in the brain, spinal cord, and peripheral autonomic ganglia that coordinates the activity of smooth and striated muscles of the bladder and urethral outlet. The neural control of micturition is organized as a hierarchical system in which spinal storage mechanisms are in turn regulated by circuitry in the rostral brain stem that initiates reflex voiding. Input from the forebrain triggers voluntary voiding by modulating the brain stem circuitry. Many neural circuits controlling the lower urinary tract exhibit switch-like patterns of activity that turn on and off in an all-or-none manner. The major component of the micturition switching circuit is a spinobulbospinal parasympathetic reflex pathway that has essential connections in the periaqueductal gray and pontine micturition center. A computer model of this circuit that mimics the switching functions of the bladder and urethra at the onset of micturition is described. Micturition occurs involuntarily in infants and young children until the age of 3 to 5 years, after which it is regulated voluntarily. Diseases or injuries of the nervous system in adults can cause the re-emergence of involuntary micturition, leading to urinary incontinence. Neuroplasticity underlying these developmental and pathological changes in voiding function is discussed.

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Purinergic cation channels in neurons of rabbit vesical parasympathetic ganglia

Cited by 18 publications

References 12 publications

Therapeutic potential of nucleotides in the eye

Therapeutic potential of nucleotides in the eye

Purinergic signalling in the urinary tract in health and disease

Neural Control of the Lower Urinary Tract

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