Purine requirements for the expression of Cape buffalo serum trypanocidal activity

Wang, Qin; Hamilton, Erika; Black, Samuel J.

doi:10.1016/s0742-8413(99)00088-2

Cited by 4 publications

(5 citation statements)

References 31 publications

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“…Several purines have been shown to elicit production of trypanocidal H 2 O 2 when added to Cape buffalo serum, some of which are not directly catabolized by XO (81). This is because serum has additional purine catabolic enzymes.…”

Section: Regulation Of Trypanocidal H 2 O 2 In Cape Buffalo Serum By mentioning

confidence: 99%

“…This is because serum has additional purine catabolic enzymes. The serum contains guanine deaminase (GA) (Kimball and Black, unpublished observations), adenosine deaminase (ADA), and purine nucleoside phosphorylase (PNP) in addition to XO (81). Upon addition to the serum, adenosine, inosine, guanosine, guanine, hypoxanthine, and xanthine are catabolized to uric acid in a series of steps, yielding H 2 O 2 as diagramed in Fig.…”

Section: Regulation Of Trypanocidal H 2 O 2 In Cape Buffalo Serum By mentioning

confidence: 99%

“…The diagram is based on data from Wang et al(81) and from Kimball and Black (unpublished observations). The symbol 6 r1p denotes the presence or absence of ribose-1-phosphate in the reaction.…”

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confidence: 99%

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Serum Xanthine Oxidase: Origin, Regulation, and Contribution to Control of Trypanosome Parasitemia

Wang

Praagh

Hamilton

et al. 2002

Antioxidants & Redox Signaling

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African trypanosomiasis is caused by Salivarian trypanosomes, tsetse fly-transmitted protozoa that inhabit the blood plasma, lymph and interstitial fluids, and, in the case of Trypanosoma brucei species, also the cerebrospinal fluid of mammal hosts. Trypanosomiasis in people and domestic animals manifests as recurring waves of parasites in the blood and is typically fatal. In contrast, trypanosomiasis in Cape buffaloes, which are naturally selected to resist the disease, is characterized by the development of only one or a few waves of parasitemia, after which the infection becomes cryptic, being maintained by the presence of 1-20 mammal-infective organisms/ml of blood. The control of the acute phase of parasitemia in Cape buffaloes correlates with a decline in blood catalase activity and the generation of trypanocidal H(2)O(2) in serum during the catabolism of endogenous purine by xanthine oxidase. Here we review features of this response, and of trypanosome metabolism, that facilitate H(2)O(2)-mediated killing of the parasites with minimal damage to the host. We also discuss the origin and regulation of serum xanthine oxidase and catalase, and show how recovery of serum catalase in infected Cape buffaloes precludes a role for H(2)O(2) in the long-term, stable suppression of trypanosome parasitemia.

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Section: Regulation Of Trypanocidal H 2 O 2 In Cape Buffalo Serum By mentioning

confidence: 99%

Section: Regulation Of Trypanocidal H 2 O 2 In Cape Buffalo Serum By mentioning

confidence: 99%

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Serum Xanthine Oxidase: Origin, Regulation, and Contribution to Control of Trypanosome Parasitemia

Wang

Praagh

Hamilton

et al. 2002

Antioxidants & Redox Signaling

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“…The mechanisms of trypano-resistance of the African buffalo have been partially investigated (e.g. Olubayo, 1991;Redruth et al, 1994;Wang et al, 2000;Guirnalda et al, 2007).…”

Section: Trypanosomiasismentioning

confidence: 99%

Infections and Parasites of Free-Ranging African Buffalo

Bengis,

Gakuya,

Munyeme

et al. 2023

Ecology and Management of the African Buffalo

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“…The mechanisms of trypano-resistance of the African buffalo have been partially investigated (e.g. Olubayo, 1991;Redruth et al, 1994;Wang et al, 2000;Guirnalda et al, 2007).…”

Section: Trypanosomiasismentioning

confidence: 99%

Ecology and Management of the African Buffalo

2023

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One of iconic Africa's Big Five, the African buffalo is the largest African bovine or antelope that occurs throughout most of sub-Sahara and in a wide range of ecosystems from savanna to rainforest. The African buffalo is also one of the most successful large African mammals in terms of abundance and biomass. This species thus represents a powerful model to enhance our understanding of African biogeography and wildlife conservation, ecology and management. Edited by four researchers experienced in different aspects of the African buffalo's biology, this volume provides an exhaustive compilation of knowledge on an emblematic species that stands out as an important component of African natural and human ecosystems. It delivers a global view of the African buffalo and all known aspects of its ecology and management. This book will appeal to students, scholars, scientists and wildlife managers as well as those enthusiastic about the charismatic species. This title is also available as Open Access on Cambridge Core.

show abstract

Purine requirements for the expression of Cape buffalo serum trypanocidal activity

Cited by 4 publications

References 31 publications

Serum Xanthine Oxidase: Origin, Regulation, and Contribution to Control of Trypanosome Parasitemia

Serum Xanthine Oxidase: Origin, Regulation, and Contribution to Control of Trypanosome Parasitemia

Infections and Parasites of Free-Ranging African Buffalo

Ecology and Management of the African Buffalo

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