Purine N-oxides. LVI. Photoisomerization of 1-hydroxy- to 3-hydroxyxanthine. Photochemistry of related 1-hydroxypurines

Chemical and biological studies on nucleic acids and derivatives. Progress report, October 1, 1974--April 30, 1975

“…Syntheses of all of the isomeric N-hydroxypurines 20 ' 25 "' 3 "* 4 "' 8 '' 57 and assays to determine their oncogenic potential 19 " 32 ' 38 ' 50 constitute one portion of this program. The synthesis of structural analogs of oncogenic N-hydroxypurines, such as N-hydroxy-derivatives of pteridines, 49 quinazolines, 51 and pyrollopyrimidines 56 are also in progress. Comparative studies of the chemistry, metabolism and oncogenic ability of these compounds with similar work on the corresponding N-hydroxypurines and selectively alkylated derivatives of them is assisting in the correlation of structural features with oncogenic requirements.…”

Photochemistry of some pteridine N-oxides

“…Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 Received July 7,1977 3-Chloro-3-methyi-I-butyne (1) has been used in C, O, and N alkylations1•2 as a convenient method for introducing the l,l-dimethyl-2-propynyl group. It has also been employed as a precursor of dimethylvinylidene carbene (2).…”