Purine metabolism in women with primary gout

Puig, Juan; Mateos, F; Miranda, Maria Eugenia; Torres, Rosa J.; Miguel, Eugenio de; Ayala, Carlos Pérez de; Gil, Amparo

doi:10.1016/0002-9343(94)90299-2

Cited by 18 publications

(11 citation statements)

References 32 publications

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“…While the findings do indicate alterations in purine metabolism, it appears that some metabolic pathways (e.g., adenine and inosine to xanthine) showed reduced catabolism, while others (e.g., xanthine to guanine and guanine to guanosine) showed enhanced catabolism. Such pattern of accumulation of certain purine metabolites and elimination of others is typical of chronic disease states, such as diabetes, gout, schizophrenia, epilepsy, and chronic kidney disease (Kristal et al 1999;Lara et al 2006;Puig et al 1994;Vianna et al 2002). There are suggestions that the purine metabolites may be involved in oxidative-stress-related toxicity of cocaine to the brain and heart (Kovacic 2005).…”

Section: Alterations In Purine Metabolismmentioning

confidence: 95%

Alterations in tryptophan and purine metabolism in cocaine addiction: a metabolomic study

et al. 2009

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Section: Alterations In Purine Metabolismmentioning

confidence: 95%

Alterations in tryptophan and purine metabolism in cocaine addiction: a metabolomic study

et al. 2009

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“…78 Serum hypoxanthine significantly increases immediately after exercise. 79 There exists a sex difference 80 but a lack of reliable data on age- or physical fitness-dependency on serum hypoxanthine.…”

Section: Biomarker For the Diagnosis Of Muscle Fatiguementioning

confidence: 99%

Muscle fatigue: general understanding and treatment

et al. 2017

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Muscle fatigue is a common complaint in clinical practice. In humans, muscle fatigue can be defined as exercise-induced decrease in the ability to produce force. Here, to provide a general understanding and describe potential therapies for muscle fatigue, we summarize studies on muscle fatigue, including topics such as the sequence of events observed during force production, in vivo fatigue-site evaluation techniques, diagnostic markers and non-specific but effective treatments.

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“…Influences on the variability of these biomarkers are largely unknown. Age-dependency of serum hypoxanthine is not well investigated but differences between the genders seem to exist [35]. No reliable data about the dependency of hypoxanthine on the physical fitness are available.…”

Section: Reviewmentioning

confidence: 99%

Biomarkers of peripheral muscle fatigue during exercise

Finsterer

2012

BMC Musculoskelet Disord

246

223

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BackgroundBiomarkers of peripheral muscle fatigue (BPMFs) are used to offer insights into mechanisms of exhaustion during exercise in order to detect abnormal fatigue or to detect defective metabolic pathways. This review aims at describing recent advances and future perspectives concerning the most important biomarkers of muscle fatigue during exercise.ResultsBPMFs are classified according to the mechanism of fatigue related to adenosine-triphosphate-metabolism, acidosis, or oxidative-metabolism. Muscle fatigue is also related to an immunological response. impaired calcium handling, disturbances in bioenergetic pathways, and genetic responses. The immunological and genetic response may make the muscle susceptible to fatigue but may not directly cause muscle fatigue. Production of BPMFs is predominantly dependent on the type of exercise. BPMFs need to change as a function of the process being monitored, be stable without appreciable diurnal variations, correlate well with exercise intensity, and be present in detectable amounts in easily accessible biological fluids. The most well-known BPMFs are serum lactate and interleukin-6. The most widely applied clinical application is screening for defective oxidative metabolism in mitochondrial disorders by means of the lactate stress test. The clinical relevance of most other BPMFs, however, is under debate, since they often depend on age, gender, physical fitness, the energy supply during exercise, the type of exercise needed to produce the BPMF, and whether healthy or diseased subjects are investigated.ConclusionsThough the role of BPMFs during fatigue is poorly understood, measuring BPMFs under specific, standardised conditions appears to be helpful for assessing biological states or processes during exercise and fatigue.

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Purine metabolism in women with primary gout

Cited by 18 publications

References 32 publications

Alterations in tryptophan and purine metabolism in cocaine addiction: a metabolomic study

Alterations in tryptophan and purine metabolism in cocaine addiction: a metabolomic study

Muscle fatigue: general understanding and treatment

Biomarkers of peripheral muscle fatigue during exercise

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