Purified rutin and rutin‐rich asparagus attenuates disease severity and tissue damage following dextran sodium sulfate‐induced colitis

Power, Krista A.; Lu, Jenifer T.; Monk, Jennifer M.; Lepp, Dion; Wu, Wenqing; Zhang, Claire; Liu, Ronghua; Tsao, Rong; Robinson, Lindsay E.; Wood, Geoffrey A.; Wolyn, David J.

doi:10.1002/mnfr.201500890

Cited by 28 publications

(18 citation statements)

References 96 publications

(154 reference statements)

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“…Our results suggested that productions of IL‐6, IL‐12, and TNF‐α were significantly reduced by TEs, whereas productions of IL‐10 were significantly increased by TEs compared to that of DSS group. These findings were similar to the previous studies, which indicated the therapeutic effects of phytochemicals enriched extracts from tea, fruits, as well as the individual phytochemicals involving epigallocatechin gallate, rutin, and free amino acids in colitis mice …”

Section: Resultsmentioning

confidence: 99%

Camellia sinensis and Litsea coreana Ameliorate Intestinal Inflammation and Modulate Gut Microbiota in Dextran Sulfate Sodium‐Induced Colitis Mice

Liu

Wang

Chen

et al. 2020

Molecular Nutrition Food Res

107

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Scope Polyphenol‐enriched herbal extracts have been proved as alternative therapeutic strategies for experimentally induced colitis. The in vivo and in vitro anti‐inflammatory effects of Camellia sinensis (green, white, yellow, oolong, black, and dark tea) and Litsea coreana (hawk tea) are comparatively explored. Methods and results HPLC analysis confirms dissimilarities among phytochemical compositions of these teas. The tea extracts (TEs) significantly decrease the production of pro‐inflammatory cytokines (IL‐6, IL‐12, and tumor necrosis factor‐α) and increase the anti‐inflammatory cytokines (IL‐10) in LPS‐stimulated RAW 264.7 macrophages and a dextran sodium sulfate (DSS)‐induced colitis mouse model. The treatment of TEs in colitis mice can ameliorate colon inflammation, pro‐oxidative enzyme activity, colon integrity, and suppress the activation of nuclear factor‐κB. Of note, green TE significantly attenuates the DSS‐induced decrease in richness and diversity of gut microbiota. Moreover, TEs are capable of exerting a prebiotic effect on gut microbiota by increasing the abundance of potentially beneficial bacteria (e.g., Faecalibaculum, and Bifidobacterium), and decreasing the abundance of potentially harmful bacteria (e.g., Bacteroids, and Mucispirillum). TEs restore the decreased production of SCFAs in the feces of colitic mice. Conclusion The treatment of seven types of tea can alleviate DSS‐induced colitis in mice, and modulate the dysbiosis of gut microbiota in colitis mice.

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Section: Resultsmentioning

confidence: 99%

Camellia sinensis and Litsea coreana Ameliorate Intestinal Inflammation and Modulate Gut Microbiota in Dextran Sulfate Sodium‐Induced Colitis Mice

Liu

Wang

Chen

et al. 2020

Molecular Nutrition Food Res

107

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“…On the other hand, the species from Butyricimonas (OTU 61092, OTU22852, and OTU43831), S24-7 (OTU52622, OTU52789, OTU67103, OTU4618, and OTU11187), Oscillospira (OTU9917), Clostridiales (OTU60609 and OTU71112), and Bilophila (OTU2261) were significantly increased by ethanol diet and markedly reversed by astaxanthin supplementation. It has been reported that the abundance of Oscillospira and Clostridales increased in inflammatory response and is associated with the barrier injury of intestinal mucosa [ 48 , 49 ]. Stanislawski et al demonstrated that Bilophila was positively correlated with the fat fraction of the liver [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Astaxanthin Prevents Alcoholic Fatty Liver Disease by Modulating Mouse Gut Microbiota

Liu

et al. 2018

Nutrients

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The development and progression of alcoholic fatty liver disease (AFLD) is influenced by the intestinal microbiota. Astaxanthin, a type of oxygenated carotenoid with strong antioxidant and anti-inflammatory properties, has been proven to relieve liver injury. However, the relationship between the gut microbiota regulation effect of astaxanthin and AFLD improvement remains unclear. The effects of astaxanthin on the AFLD phenotype, overall structure, and composition of gut microbiota were assessed in ethanol-fed C57BL/6J mice. The results showed that astaxanthin treatment significantly relieves inflammation and decreases excessive lipid accumulation and serum markers of liver injury. Furthermore, astaxanthin was shown to significantly decrease species from the phyla Bacteroidetes and Proteobacteria and the genera Butyricimonas, Bilophila, and Parabacteroides, as well as increase species from Verrucomicrobia and Akkermansia compared with the Et (ethanol)group. Thirteen phylotypes related to inflammation as well as correlated with metabolic parameters were significantly altered by ethanol, and then notably reversed by astaxanthin. Additionally, astaxanthin altered 18 and 128 KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways involved in lipid metabolism and xenobiotic biodegradation and metabolism at levels 2 and 3, respectively. These findings suggest that Aakkermansia may be a potential target for the astaxanthin-induced alleviation of AFLD and may be a potential treatment for bacterial disorders induced by AFLD.

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“…Dietary factors might also modulate Rac1 activity, and consequently might strengthen intestinal barrier activity under physiological conditions or alleviate inflammatory severity and mucosal restitution following resolution of inflammation. In this context, Rutin-rich asparagus and black beans attenuate DSS-induced colitis by modulating the colonic microbiota, resulting in improved barrier integrity and upregulation of effectors of injury repair, including Rac1 [78,79].…”

Section: Intestinal Barrier Integrity/mucosal Repair/colitismentioning

confidence: 99%

Rac1 Signaling: From Intestinal Homeostasis to Colorectal Cancer Metastasis

Kotelevets

Chastre

2020

Cancers

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The small GTPase Rac1 has been implicated in a variety of dynamic cell biological processes, including cell proliferation, cell survival, cell-cell contacts, epithelial mesenchymal transition (EMT), cell motility, and invasiveness. These processes are orchestrated through the fine tuning of Rac1 activity by upstream cell surface receptors and effectors that regulate the cycling Rac1-GDP (off state)/Rac1-GTP (on state), but also through the tuning of Rac1 accumulation, activity, and subcellular localization by post translational modifications or recruitment into molecular scaffolds. Another level of regulation involves Rac1 transcripts stability and splicing. Downstream, Rac1 initiates a series of signaling networks, including regulatory complex of actin cytoskeleton remodeling, activation of protein kinases (PAKs, MAPKs) and transcription factors (NFkB, Wnt/β-catenin/TCF, STAT3, Snail), production of reactive oxygen species (NADPH oxidase holoenzymes, mitochondrial ROS). Thus, this GTPase, its regulators, and effector systems might be involved at different steps of the neoplastic progression from dysplasia to the metastatic cascade. After briefly placing Rac1 and its effector systems in the more general context of intestinal homeostasis and in wound healing after intestinal injury, the present review mainly focuses on the several levels of Rac1 signaling pathway dysregulation in colorectal carcinogenesis, their biological significance, and their clinical impact.

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Purified rutin and rutin‐rich asparagus attenuates disease severity and tissue damage following dextran sodium sulfate‐induced colitis

Cited by 28 publications

References 96 publications

Camellia sinensis and Litsea coreana Ameliorate Intestinal Inflammation and Modulate Gut Microbiota in Dextran Sulfate Sodium‐Induced Colitis Mice

Camellia sinensis and Litsea coreana Ameliorate Intestinal Inflammation and Modulate Gut Microbiota in Dextran Sulfate Sodium‐Induced Colitis Mice

Astaxanthin Prevents Alcoholic Fatty Liver Disease by Modulating Mouse Gut Microbiota

Rac1 Signaling: From Intestinal Homeostasis to Colorectal Cancer Metastasis

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