Purified Dry Extract of<i>Paullinia cupana</i>(Guaraná) (PC-18) for Chemotherapy-Related Fatigue in Patients with Solid Tumors: An Early Discontinuation Study

Giglio, Adriana Braz del; Cubero, Daniel de Iracema Gomes; Lerner, Tatiana Goberstein; Guariento, Ricardo tuma; Azevedo, Rui; Paiva, Henrique Soares; Goldman, Cecilia; Carelli, Bruno; Cruz, Felipe Melo; Schindler, Fernanda; Pianowski, Luiz F.; Matos, Leandro Luongo de; Giglio, Auro del

doi:10.3109/19390211.2013.830676

Cited by 34 publications

(16 citation statements)

References 23 publications

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“…Guarana possesses biological properties described in the literature as anti-inflammatory (29), antidepressant (30), panicolytic (31) and energetic (6), which may help minimize CRF, as previously reported (7,8). Other studies have also described the antitumor activity of guarana using animal and cell experimental models (32)(33)(34).…”

Section: Discussionmentioning

confidence: 81%

Effect of Paullinia cupana on MCF-7 breast cancer cell response to chemotherapeutic drugs

Hertz

Cadoná

Machado

et al. 2014

Molecular and Clinical Oncology

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Abstract. Previous studies suggested that certain plants, such as guarana (Paullinia cupana), exert a protective effect against cancer-related fatigue in breast cancer patients undergoing chemotherapy. However, guarana possesses bioactive molecules, such as caffeine and catechin, which may affect the pharmacological properties of antitumor drugs. Therefore, the aim of this study was to evaluate the effects of guarana on breast cancer cell response to 7 chemotherapeutic agents currently used in the treatment of breast cancer. To perform this study, MCF-7 breast cancer cells were cultured under controlled conditions and exposed to 1, 5 and 10 µg/ml guarana concentrations, with and without chemotherapeutics (gemcitabine, vinorelbine, methotrexate, 5-fluorouracil, paclitaxel, doxorubicin and cyclophosphamide). The effect of these treatments on MCF-7 cell viability and proliferation was spectrophotometrically analyzed with the MTT assay. The main results demonstrated an antiproliferative effect of guarana at concentrations of 5 and 10 µg/ml and a significant effect on chemotherapeutic drug action. In general, guarana improved the antiproliferative effect of chemotherapeutic agents, causing a decrease of >40% in cell growth after 72 h of exposure. The results suggested an interaction of guarana with the chemotherapeutic drugs, which requires confirmation by in vivo complementary studies.

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Section: Discussionmentioning

confidence: 81%

Effect of Paullinia cupana on MCF-7 breast cancer cell response to chemotherapeutic drugs

Hertz

Cadoná

Machado

et al. 2014

Molecular and Clinical Oncology

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“…In a large, rigorously conducted, double‐blind, placebo‐controlled trial in cancer survivors, Wisconsin ginseng (an 8‐week course of 2000 mg daily) improved fatigue outcomes and was well tolerated . However, inconsistent effects on fatigue outcomes have been observed in studies of other nutritional supplements and herbal remedies, including vitamin supplements, multicomponent nutritional supplementation, coenzyme Q10, levocarnitine, lectin‐standardized mistletoe, omega‐3 fatty acid supplements in combination with megestrol acetate, protein supplementation in combination with nutritional counseling, gaurana, Chinese herbal medicine, essiac, and valerian …”

Section: Evidence‐based Summary Of Nonpharmacologic Interventionsmentioning

confidence: 99%

Screening, evaluation, and management of cancer‐related fatigue: Ready for implementation to practice?

Berger

Mitchell

Jacobsen

et al. 2015

CA A Cancer J Clinicians

145

141

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Answer questions and earn CME/CNE Evidence regarding cancer-related fatigue (fatigue) has accumulated sufficiently such that recommendations for screening, evaluation, and/or management have been released recently by 4 leading cancer organizations. These evidence-based fatigue recommendations are available for clinicians, and some have patient versions; but barriers at the patient, clinician, and system levels hinder dissemination and implementation into practice. The underlying biologic mechanisms for this debilitating symptom have not been elucidated completely, hindering the development of mechanistically driven interventions. However, significant progress has been made toward methods for screening and comprehensively evaluating fatigue and other common symptoms using reliable and valid self-report measures. Limited data exist to support the use of any pharmacologic agent; however, several nonpharmacologic interventions have been shown to be effective in reducing fatigue in adults. Never before have evidence-based recommendations for fatigue management been disseminated by 4 premier cancer organizations (the National Comprehensive Cancer, the Oncology Nursing Society, the Canadian Partnership Against Cancer/Canadian Association of Psychosocial Oncology, and the American Society of Clinical Oncology). Clinicians may ask: Are we ready for implementation into practice? The reply: A variety of approaches to screening, evaluation, and management are ready for implementation. To reduce fatigue severity and distress and its impact on functioning, intensified collaborations and close partnerships between clinicians and researchers are needed, with an emphasis on system-wide efforts to disseminate and implement these evidence-based recommendations.

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“…Recent work also examined the use of guarana to counter fatigue and depression associated with cancer treatment [26–28]. The main component of guarana attributed to these beneficial properties is caffeine, which, depending on how the extract is prepared, can be more than four times the amount found in coffee beans [19, 29].…”

Section: Introductionmentioning

confidence: 99%

Guarana Provides Additional Stimulation over Caffeine Alone in the Planarian Model

et al. 2015

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The stimulant effect of energy drinks is primarily attributed to the caffeine they contain. Many energy drinks also contain other ingredients that might enhance the tonic effects of these caffeinated beverages. One of these additives is guarana. Guarana is a climbing plant native to the Amazon whose seeds contain approximately four times the amount of caffeine found in coffee beans. The mix of other natural chemicals contained in guarana seeds is thought to heighten the stimulant effects of guarana over caffeine alone. Yet, despite the growing use of guarana as an additive in energy drinks, and a burgeoning market for it as a nutritional supplement, the science examining guarana and how it affects other dietary ingredients is lacking. To appreciate the stimulant effects of guarana and other natural products, a straightforward model to investigate their physiological properties is needed. The planarian provides such a system. The locomotor activity and convulsive response of planarians with substance exposure has been shown to provide an excellent system to measure the effects of drug stimulation, addiction and withdrawal. To gauge the stimulant effects of guarana we studied how it altered the locomotor activity of the planarian species Dugesia tigrina. We report evidence that guarana seeds provide additional stimulation over caffeine alone, and document the changes to this stimulation in the context of both caffeine and glucose.

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Purified Dry Extract ofPaullinia cupana(Guaraná) (PC-18) for Chemotherapy-Related Fatigue in Patients with Solid Tumors: An Early Discontinuation Study

Cited by 34 publications

References 23 publications

Effect of Paullinia cupana on MCF-7 breast cancer cell response to chemotherapeutic drugs

Effect of Paullinia cupana on MCF-7 breast cancer cell response to chemotherapeutic drugs

Screening, evaluation, and management of cancer‐related fatigue: Ready for implementation to practice?

Guarana Provides Additional Stimulation over Caffeine Alone in the Planarian Model

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